Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis

Authors:

Sam Alsford

doi: 10.15698/mic2014.08.162
Volume 1, pp. 270 to 272, published 14/07/2014.

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Affiliations:

London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

Keywords: 

Trypanosoma brucei, trypanolysis, cathepsin-L, innate immunity, lysosome.

Corresponding Author(s):

Sam Alsford, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK sam.alsford@lshtm.ac.uk

Conflict of interest statement:

I have no conflicts of interest.

Please cite this article as:

Sam Alsford (2014). Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis. Microbial Cell 1(8): 270-272.

© 2014 Alsford. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

Abstract:

Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action.