Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
Authors:Sam Alsford
London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Keywords:
Trypanosoma brucei, trypanolysis, cathepsin-L, innate immunity, lysosome.
Related Article(s)?
Sam Alsford, Rachel B. Currier, José Afonso Guerra-Assunção, Taane G. Clark, David Horn (2014). Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei. PLoS Pathogens 2014: 10, e1004130., 10.1371/journal.ppat.1004130
Corresponding Author(s):
Conflict of interest statement:
I have no conflicts of interest.
Please cite this article as:
Sam Alsford (2014). Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis. Microbial Cell 1(8): 270-272.
© 2014 Alsford. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action.
doi: 10.15698/mic2014.08.162
Volume 1, pp. 270 to 272, published 14/07/2014.