Affiliations: 1 Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria.
2 Division of Endocrinology and Metabolism, Dept. of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
# These authors contributed equally to this work.
Keywords:
autophagy, aging, metabolism, acetyl-CoA, polyamines, amino acids.
Related Article(s)?
Corresponding Author(s):
Frank Madeo, Humboldtstrasse 50; 8010 Graz, Austria frank.madeo@uni-graz.at
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Sabrina Schroeder, Andreas Zimmermann, Didac Carmona-Gutierrez, Tobias Eisenberg, Christoph Ruckenstuhl, Aleksandra Andryushkova, Tobias Pendl, Alexandra Harger and Frank Madeo (2014). Metabolites in aging and autophagy. Microbial Cell 1(4): 110-114.
© 2014 Schroeder et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Metabolites in aging and autophagy
Authors:Sabrina Schroeder1,#, Andreas Zimmermann1,#, Didac Carmona-Gutierrez1, Tobias Eisenberg1, Christoph Ruckenstuhl1, Aleksandra Andryushkova1, Tobias Pendl1, Alexandra Harger1,2 and Frank Madeo1
1 Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria.
2 Division of Endocrinology and Metabolism, Dept. of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
# These authors contributed equally to this work.
Keywords:
autophagy, aging, metabolism, acetyl-CoA, polyamines, amino acids.
Related Article(s)?
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Sabrina Schroeder, Andreas Zimmermann, Didac Carmona-Gutierrez, Tobias Eisenberg, Christoph Ruckenstuhl, Aleksandra Andryushkova, Tobias Pendl, Alexandra Harger and Frank Madeo (2014). Metabolites in aging and autophagy. Microbial Cell 1(4): 110-114.
© 2014 Schroeder et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Autophagy, the main lysosomal degradative machinery, plays a major role in maintaining cellular homeostasis and thus a healthy state in an organism. This process recycles unnecessary or damaged material, therefore, not only providing nutrients to maintain vital cellular functions in times of starvation but also eliminating potentially harmful cellular material. Importantly, the autophagic rate declines with increasing age, suggesting a functional correlation between aging and autophagy. Indeed, the deregulation of autophagy is involved in the onset of various age-related diseases such as cancer, cardiomyopathy, type II diabetes, and neurodegeneration. Until recently, aging was regarded as an unregulated and inescapable consequence of the accumulation of incidental damage in macromolecules and/or organelles. However, the discovery of multiple ways to extend the lifespan in a variety of different model organisms, e.g., by genetic and pharmacological means, developed the formulation of alternative aging theories that consider aging as a molecular program. Indeed, the last years have provided important insights into the networks that control aging and have thus highlighted the interconnected nature of aging and various cellular processes. For instance, the process of aging is intimately coupled to metabolic processes, in particular to energy metabolism and nutrient availability. Nevertheless, specific metabolites that affect aging and autophagy remain poorly described.
doi: 10.15698/mic2014.04.142
Volume 1, pp. 110 to 114, published 07/04/2014.