Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control
Authors:R. Jürgen Dohmen
doi: 10.15698/mic2015.10.235
Volume 2, pp. 356 to 359, published 05/10/2015.
Institute for Genetics, University of Cologne, Zülpicher Str. 47, D-50674 Cologne, Germany.
Keywords:
N-end rule, formyl-methionine, acetylation, FtsH, proteasome, ubiquitin, quality control
Corresponding Author(s):
Conflict of interest statement:
The author declares no conflict of interest.
Please cite this article as:
R. Jürgen Dohmen (2015). Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control. Microbial Cell 2(10): 356-359.
© 2015 Dohmen. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
In this article, the author comments on the study “Formyl-methionine as a degradation signal at the N-termini of bacterial proteins.” by Piatkov et al. (Microbial Cell, 2015), discussing a novel N-terminal degradation signal (N-degron) that targets nascent proteins for degradation in Escherichia coli by a new branch of the bacterial N-end rule pathway, termed the fMet/N-end rule pathway