The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae
Authors:Subhadeep Das1, Debasish Sarkar2 and Biswadip Das1
doi: 10.15698/mic2017.07.580
Volume 4, pp. 212 to 228, published 03/07/2017.
1 Department of Life Science and Biotechnology, Jadavpur University, Kolkata, India.
2 Present Address: Laboratory of Molecular Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12201-2002, USA.
Keywords:
promoter, mRNA degradation, transcription, functional coupling, Rpb4/7, SWI5, CLB2, RPL30, mRNA mark, coordinator.
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Subhadeep Das, Debasish Sarkar and Biswadip Das (2017). The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae. Microbial Cell 4(7):212-228. doi: 10.15698/mic2017.07.580
© 2017 Das et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
The cellular transcriptome is shaped by both the rates of mRNA synthesis in the nucleus and mRNA degradation in the cytoplasm under a specified condition. The last decade witnessed an exciting development in the field of post-transcriptional regulation of gene expression which underscored a strong functional coupling between the transcription and mRNA degradation. The functional integration is principally mediated by a group of specialized promoters and transcription factors that govern the stability of their cognate transcripts by “marking” them with a specific factor termed “coordinator.” The “mark” carried by the message is later decoded in the cytoplasm which involves the stimulation of one or more mRNA-decay factors, either directly by the “coordinator” itself or in an indirect manner. Activation of the decay factor(s), in turn, leads to the alteration of the stability of the marked message in a selective fashion. Thus, the integration between mRNA synthesis and decay plays a potentially significant role to shape appropriate gene expression profiles during cell cycle progression, cell division, cellular differentiation and proliferation, stress, immune and inflammatory responses, and may enhance the rate of biological evolution.