Biofilm tolerance, resistance and infections increasing threat of public health

Authors:

Shanshan Yang1,3, Xinfei Li1,2, Weihe Cang1,2, Delun Mu1,3, Shuaiqi Ji1,3, Yuejia An1, Rina Wu1,2,3 and Junrui Wu1,2,3

doi: 10.15698/mic2023.11.807
Volume 10, pp. 233 to 247, published 26/09/2023.

PDF Download PubMed Link
Affiliations:

1 College of Food Science, Shenyang Agricultural University, Shenyang 110866, P.R. China.
2 Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang 110866, P.R. China.
3 Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang 110866, P.R. China.

Keywords: 

biofilm, tolerance, resistance, diseases, intervention.

Corresponding Author(s):

Rina Wu, College of Food Science, Shenyang Agricultural University, Shenyang 110866, P.R. China; wrn6956@163.com Junrui Wu, College of Food Science, Shenyang Agricultural University, Shenyang 110866, P.R. China; junruiwu@126.com

Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

Shanshan Yang, Xinfei Li, Weihe Cang, Delun Mu, Shuaiqi Ji, Yue-jia An, Rina Wu and Junrui Wu (2023). Biofilm tolerance, resistance and infections increasing threat of public health. Microbial Cell 10(11): 233-247. doi: 10.15698/mic2023.11.807

© 2023 Yang et al.. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

Abstract:

Microbial biofilms can cause chronic infection. In the clinical setting, the biofilm-related infections usually persist and reoccur; the main reason is the increased antibiotic resistance of biofilms. Traditional antibiotic therapy is not effective and might increase the threat of antibiotic resistance to public health. Therefore, it is urgent to study the tolerance and resistance mechanism of biofilms to antibiotics and find effective therapies for biofilm-related infections. The tolerance mechanism and host reaction of biofilm to antibiotics are reviewed, and bacterial biofilm related diseases formed by human pathogens are discussed thoroughly. The review also explored the role of biofilms in the development of bacterial resistance mechanisms and proposed therapeutic intervention strategies for biofilm related diseases.