Evidence for the hallmarks of human aging in replicatively aging yeast
Authors:Georges E. Janssens, Liesbeth M. Veenhoff
doi: 10.15698/mic2016.07.510
Volume 3, pp. 263 to 274, published 20/06/2016.
European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Keywords:
hallmarks of aging, human, replicative aging, yeast.
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Georges E. Janssens, Liesbeth M. Veenhoff (2016). Evidence for the hallmarks of human aging in replicatively aging yeast. Microbial Cell 3(7): 263-274. doi: 10.15698/mic2016.07.510
© 2016 Janssens and Veenhoff. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Abstract:
Recently, efforts have been made to characterize the hallmarks that accompany and contribute to the phenomenon of aging, as most relevant for humans [cite]10.1016/j.cell.2013.05.039[/cite]. Remarkably, studying the finite lifespan of the single cell eukaryote budding yeast (recently reviewed in [cite]10.1111/1574-6976.12060[/cite] and [cite]10.1111/1567-1364.12104[/cite]) has been paramount for our understanding of aging. Here, we compile observations from literature over the past decades of research on replicatively aging yeast to highlight how the hallmarks of aging in humans are present in yeast. We find strong evidence for the majority of these, and summarize how yeast aging is especially characterized by the hallmarks of genomic instability, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, and mitochondrial dysfunction.