A novel mechanism involved in the coupling of mitochondrial biogenesis to oxidative phosphorylation
Authors:Jelena Ostojić1, Jean-Paul di Rago2,3, Geneviève Dujardin1,*
doi: 10.15698/mic2014.01.123
Volume 1, pp. 43 to 44, published 06/01/2014.
1 Centre de Génétique Moléculaire, Université Paris-Sud, avenue de la Terrasse, 91190 Gif sur Yvette, France
2 University Bordeaux, Institut de Biochimie et Génétique Cellulaires, UMR 5095, 33000 Bordeaux, France
3 CNRS, Institut de Biochimie et Génétique Cellulaires, UMR 5095, 33000 Bordeaux, France
Keywords:
yeast, mitochondrial-disease model, AAA protein Bcs1, OXPHOS complex III, ATP synthase
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Jelena Ostojić, Jean-Paul di Rago, Geneviève Dujardin (2014). A novel mechanism involved in the coupling of mitochondrial biogenesis to oxidative phosphorylation. Microbial Cell 1(1): 43-44.
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Abstract:
Mitochondria are essential organelles that are central to a multitude of cellular processes, including oxidative phosphorylation (OXPHOS), which produces most of the ATP in animal cells. Thus it is important to understand not only the mechanisms and biogenesis of this energy production machinery but also how it is regulated in both physiological and pathological contexts. A recent study by Ostojić et al. [Cell Metabolism (2013) 18, 567-577] has uncovered a regulatory loop by which the biogenesis of a major enzyme of the OXPHOS pathway, the respiratory complex III, is coupled to the energy producing activity of the mitochondria.