FIGURE 6: FTY720-sensitive gene-deletion cells exhibited deregulated ROS levels in the absence/presence of FTY720 or H₂O₂. (A) The RRL in the 26 FTY720-sensitive mutants displayed 150% higher than that in the wt strain in the absence of any ROS-inducing agents. (B) The RRL in the 18 FTY720-sensitive mutants displayed 150% higher than that in the wt strain upon FTY720 treatment. (C) Ratios of ROS levels between after and before the FTY720 stimuli in comparison with those of the wt strain. (D) The RRL in the 36 FTY720-sensitive mutants displayed 150% higher than that in the wt strain upon H₂O₂ treatment. (E) Ratios of ROS levels between after and before the H₂O₂ stimuli in comparison with those of the wt strain. These ROS accumulations were measured for 3 h. The data were averaged from three independent experiments. Error bars, SD.