Editorial Board

Meet Microbial Cell’s editorial board, which includes renowned scientists in diverse fields of unicellular and mammalian research warranting the quality of our published articles.

 

 

Editors-in-Chief

Portrait of Frank Madeo

Frank Madeo is a professor at the Institute for Molecular Biosciences at the University of Graz. He discovered and initiated the field of yeast apoptosis and has since then focused his research on the identification and characterization of conserved regulators and mechanisms of programmed cell death. At the same time, he investigates the function and control of pathways and processes underlying aging from yeast to mice, which recently led to the identification of spermidine as an autophagy inducer with anti-aging properties.

Portrait of Guido Kroemer

He is currently professor at the Faculty of Medicine (University of Paris Descartes) and additionally affiliated to the French Medical Research Council (INSERM), the Institut Gustave Roussy, and the Hôpital Européen Georges-Pompidou (Paris). His lab discovered the fundamental role of mitochondrial permeabilization in programmed cell death and has ever since continued to elucidate the role of mitochondria in pathological cell death. Additionally, he is interested in the regulation and function of autophagy in disease processes and the contribution of immune response to dying cancer cells.

Portrait of Didac Carmona-Gutierrez

He studied and worked at the University of Tübingen, the University of Washington, and the Technical University of Graz and is currently an Assistant Professor at the Institute for Molecular Biosciences at the University of Graz. His research mainly focuses on deciphering the mechanisms underlying apoptotic and non-apoptotic programmed cell death employing yeast as a model organism. Furthermore, he is interested in devising pharmacological approaches to counteract aging-related cellular and organismal dysfunctions.

Managing Editors

Portrait of Katharina Kainz

She studied molecular microbiology at the University of Graz (Austria) and is currently doing her PhD at the Institute of Molecular Biosciences at the University of Graz. Her research focuses on metabolic anti-aging properties of dietary compounds. Furthermore, she is interested in the investigation of molecular mechanisms leading to Huntington’s disease using yeast as a model system.

Editorial Assistants

Portrait of Thomas Heger

Thomas Heger studied biochemistry at the University of Tübingen (Germany), the University of Washington (Seattle, USA) as well as the Ludwig-Maximilians-University in Munich (Germany). He obtained his PhD at the Swiss Federal Institute of Technology in Zürich (Switzerland), in Cell- and Systems Biology and Virology where he specialized in software development.

Portrait of Andreas Zimmermann

He studied microbiology and biochemistry at the University of Graz (Austria) and the Technical University of Graz (Austria) and is currently doing his PhD at the Institute for Molecular Biosciences at the University of Graz. His research focus lies on mitochondrial regulation of cell death and aging using yeast as a model. He is also investigating pharmacological approaches to decelerate age-associated malfunctions.

Founding Editorial Board

Portrait of Rafael de Cabo

Rafael de Cabo is a senior investigator at the National Institute on Aging (National Institutes of Health, USA) and an active member of the Board of the American Aging Association. His research focuses on the molecular pathways underlying the impact of caloric restriction on aging and investigates the effects and mechanisms of pharmacological and other anti-aging interventions.

Portrait of Lorenzo Galluzzi

Lorenzo Galluzzi studied at the University of Modena and Reggio Emilia and at the University of Paris Sud/Paris XI. He is a founding member of the European Research Institute for Integrated Cellular Pathology and an editor for several scientific journals in the field of oncology, among others Editor-in-Chief of “OncoImmunology”. His research as part of the Research Unit "Apoptosis, Cancer and Immunity" focuses on several aspects of mitochondrial cell death, autophagy, oncogenic signaling pathways and tumor immunology.

Portrait of Brian K. Kennedy

He is President and CEO of the Buck Institute for Research on Aging (California, USA). During his graduate studies at the Massachusetts Institute of Technology (USA) in Leonard Guarentes laboratory, he contributed decisively to the discovery of Sirtuins as aging modulators. His current research involves nutrient signaling pathways linked to dietary restriction, particularly the TOR pathway. He also studies A-type nuclear lamins, which are targets for mutation in Hutchinson-Gilford progeria syndrome.

Portrait of Thomas Langer

After working at the Memorial Sloan Kettering Cancer Center (New York) and the Ludwig-Maximilian-University of Munich, he is now a professor at the Institute for Genetics of the University of Cologne. His research interests concentrate on deciphering the (proteolytic) mechanisms of mitochondrial quality control using yeast and mice as model systems. In addition, he analyzes the pathogenic relevance of the mitochondrial proteolytic system, for instance in neurodegenerative disorders.

Portrait of Valter Longo

He is currently a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biological Sciences as well as serving as the director of the USC Longevity Institute. His research focuses on the elucidation of fundamental mechanisms and conserved molecular pathways of aging from yeast to mice and humans. He is equally interested in strategies to modulate such pathways to protect against or ameliorate the reaction to different stresses and aging-associated diseases, among others cancer and its chemotherapeutic treatment.

Portrait of Chris Meisinger

Chris Meisinger studied and obtained his PhD at the Albert-Ludwigs-University of Freiburg and is currently a professor at the Institute of Biochemistry and Molecular Biology and the Center of Biological Signaling Studies (University of Freiburg). His lab is interested in the mitochondrial proteome with emphasis on mitochondrial protein import pathways, signaling and turnover. Moreover, he investigates the role of mitochondria in the regulation of programmed cell death.

Portrait of Thomas Nyström

Thomas Nyström is a member of the Royal Swedish Academy of Sciences and a professor at the Department of Chemistry and Molecular Biology of the University of Gothenburg. Using the model organisms Escherichia coli, Saccharomyces cerevisiae and mouse embryonic stem cells, his group investigates the molecular mechanisms governing cellular deterioration during aging. At the same time, he focuses on elucidating the processes by which aging phenotypes are abolished in the progeny during rejuvenation.

Portrait of Jared Rutter

After studies at the Brigham Young University (Utah) and at the University of Texas Southwestern Medical Center, he is now an associate professor in the Department of Biochemistry at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute. His research is centered upon deciphering the molecular factors involved in cellular metabolic control. This has led him to explore the mitochondrial proteome, metabolite-based allostery and energy-sensing pathways.

Academic Editors

Portrait of Andrés  Aguilera

Editor's portrait and information coming up soon.

Portrait of Aleksandra Andryushkova

She studied at Novosibirsk State University (Russia), University of Stuttgart (Germany) and at the Institute for Molecular Biotechnology at the Graz University of Technology (Austria), where she obtained her PhD. She is currently a researcher at the Institute for Molecular Biosciences at the University of Graz (Austria), where she investigates the metabolic and epigenetic control of the interplay between aging processes and autophagy.

Portrait of Luis  Aragon

Luis Aragon is currently a Professor at Imperial College London (UK) and Group Leader at the MRC Clinical Sciences Centre. His laboratory studies molecular mechanisms orchestrating the equal and faithful segregation of chromosomes during cellular division. His group is focused on the analysis of protein complexes that mediate chromosome structure and segregation, namely cohesin, condensin and a novel complex, the SMC5/6 complex. In addition, his laboratory is interested in regulatory networks that operate to coordinate different aspects of the chromosome metabolism, including DNA replication, DNA repair and chromosome segregation with cell cycle progression.

Portrait of Joaquín  Ariño

His research essentially deals with (i) the role of phospho-dephosphorylation mechanisms in the reponse to stress in yeasts and (ii) the overall mechanisms that allow proper regulation of monovalent cation homeostasis.

Portrait of Mark Ashe

Mark Ashe's lab works on a variety of stress responses and their effects on protein synthesis, mRNA fate and translation factor localisation in the budding yeast Saccharomyces cerevisiae. Studies on alcohols in terms of stress in yeast have also led to an interest in biofuel production using yeast. This has opened up new areas such as metabolic engineering and synthetic biology.

Portrait of Nicanor  Austriaco

He currently serves as an Associate Professor of Biology and an Instructor of Theology at Providence College in Providence, Rhode Island (USA). He earned his Ph.D. in the laboratory of Leonard Guarente at M.I.T. where he was a pre-doctoral fellow of the Howard Hughes Medical Institute (HHMI), and his S.T.L. from the Dominican House of Studies in Washington, D.C. At the present time, he is completing a Doctorate in Sacred Theology (S.T.D.) at the University of Fribourg (Switzerland). His laboratory is investigating the genetics of programmed cell death using the yeasts Saccharomyces cerevisiae and Candida albicans as model organisms.

Portrait of Kathryn  Ayscough

Kathryn Ayscough's lab works on understanding the mechanism and regulation of endocytosis in Saccharomyces cerevisiae. Her group has a particular interest in how the actin cytoskeleton is able to stablize the endocytic site and drive invagination of the plasma membrane and, also in how the dynamin-like protein Vps1 co-operates with amphiphysins to bring about scission of the endocytic vesicle.

Portrait of Markus  Babst

Editor's portrait and information coming up soon.

Portrait of Anand K Bachhawat

Anand K Bachhawat has a PhD in Biochemistry from the University of Calcutta (India) and has done post-doctoral studies at the MGH Cancer Center, Harvard Medical School, Boston (USA) and the Department of Biology, Carnegie Mellon University, Pittsburgh (USA). He is currently a Professor in the Department of Biological Sciences at the Indian Institute of Science Education and Research, Mohali (India). His research interests are in glutathione and cysteine homeostasis in Saccharomyces cerevisiae.

Portrait of Jürg  Bähler

Jürg Bähler is currently a Professor at University College London (UK). His laboratory studies genome regulation during cellular quiescence, ageing and stress response using fission yeast as a model system. His group applies multiple genetic, computational and genome-wide approaches for systems-level understanding of complex relationships between genotype, phenotype and environment, including roles of genome variation and evolution, transcriptome regulation, and non-coding RNAs.

Portrait of Adam  Bailis

The Bailis laboratory investigates the genetic and molecular control of eukaryotic genome stability using Saccharomyces cerevisiae as a model organism. His group has focused primarily on responses by the homologous recombination machinery to defined DNA double-strand breaks, defective DNA replication and telomere uncapping. This work suggests that the genetic control of the balance between homologous recombination mechanisms that conserve and those that alter chromosome structure is a critical determinant of genome stability.

Portrait of Shoshana  Bar-Nun

Her lab is studying the aging - neurodegeneration link in a yeast model. In neurodegenerative disorders manifested by protein aggregation, aging is the major risk factor. Her group focuses on effects of aging on quality control mechanisms that cope with proteins aggregates. In particular, her lab studies a poly-glutamine protein that is soluble in young cells but aggregates as the yeast age. This aging-dependent aggregation allows the screening for pro- and anti-aging genes, cellular pathways and drugs.

Portrait of Antonio  Barrientos

Editor's portrait and information coming up soon.

Portrait of Florian F  Bauer

Florian Bauer studied in France at the Université de Bordeaux (France), and today is professor in Wine Biotechnology and holder of the South African Research Chair in Integrated Wine Science at Stellenbosch University (South Africa). His research is primarily focused on the ecology and molecular biology of the yeast Saccharomyces cerevisiae, with particular attention being paid to the specific properties of wine yeast strains. Projects in his research group are using system-wide cross-omic analysis tools to study interactions between different yeast species and strains, the genetic control of metabolism, the cell wall and adhesion properties as well as the molecular impact of therapeutic compounds such as carnitine in eukaryotic systems.

Portrait of Peter Belenky

His work focuses on studying the responses of microbial communities and isolated microbes to external stress such as antimicrobial agents. Understanding how these extracellular stressors affect our microbiome will provide critical biological insight into the development of dysbiosis, disease, and antibiotic resistance. Relying on recent advances in high-throughput DNA and RNA sequencing, his lab is studying the effects of antimicrobial agents on these highly complex microbial communities to identify microbial mechanisms that lead to improved antimicrobial tolerance and the development of resistance.

Portrait of Stefan Benke

He studied molecular microbiology at the University of Graz and is currently affiliated to the Max F. Perutz Laboratories (University of Vienna). His interests include the deregulation of calcium homeostasis in Parkinson's Disease using budding yeast as a model organism. His present research focuses on the innate immune system and its regulation through ubiquitination during infection and inflammatory disease.

Portrait of Anders  Blomberg

Anders Blomberg is professor in Functional Genomics at the Department of Chemistry and Molecular Biology of the University of Gothenburg (Sweden). He has an interest in molecular mechanisms involved in various stress responses e.g. osmotic dehydration, oxidative stress, light-sensitivity, mainly examined in the model yeast Saccharomyces cerevisiae but also in a number of marine organisms. High-resolution yeast phenomics is a key-activity where he investigates the finer details of the genotype-phenotype map and explores the potential for surrogate genetics via ectopic expression of genes/alleles from humans and marine species. He also leads ten ongoing marine genome projects.

Portrait of Marc  Blondel

Marc Blondel is Professor of Cell Biology at the Medical School of the University of Brest (France). He has expertise in yeast (Saccharomyces cerevisiae) genetics and molecular biology. His group develops yeast models for various human diseases, including neurodegenerative disorders (especially prion-based diseases), cancers and mitochondrial diseases. The basic idea is to obtain a yeast phenotype that is relevant for the considered disorders and then to look for modifiers of this phenotype. These modifiers can be positive or negative (that is, they may either suppress or exacerbate the phenotype) and they can be drugs or genes or any other biological or chemical moiety. These modifiers are then validated on mammalian cell-based models and then, if possible, in vivo.

Portrait of Ralf Braun

Editor's portrait and information coming up soon.

Portrait of Sigurd Braun

Our research focuses on understanding regulatory mechanisms of heterochromatin formation in the fission yeast S. pombe. Lately, we have been studying the spatial regulation of heterochromatin boundaries by ubiquitin-dependent protein degradation (‘chromatin sculpting’) and the intranuclear positioning of silent chromatin by the conserved inner nuclear membrane protein Lem2. In addition, we are dissecting regulator pathways and networks of silent chromatin using functional genomics and systems approaches.

Portrait of Michael  Breitenbach

His research is now centered on yeast as an aging model, mitochondria, and NADPH oxidases.

Portrait of Jason H.  Brickner

The localization of DNA within the nucleus is controlled and has important effects on nuclear functions. The Brickner lab uses yeast and metazoan models to 1) define the molecular mechanisms by which DNA can be directed to different subnuclear environments and 2) determine the functional significance of subnuclear localization of DNA on transcription and chromatin structure.

Portrait of Carlo V.  Bruschi

Carlo V. Bruschi was an NIH post-doctoral fellow at the Lawrence Berkeley National Laboratory (LBL) of the University of California at Berkeley (USA), then a tenure-track assistant professor and later a tenured associate professor in the Department of Microbiology and Immunology of the East Carolina University School of Medicine (USA). Since 1990 he is a senior scientist and group leader of the Yeast Molecular Biology Group of ICGEB in Trieste (Italy), where he has pioneered the field of chromosomal translocations induced in vivo, by designing the bridge-induced translocation (BIT) system to construct ad hoc translocations at pre-defined genomic loci, using the yeast Saccharomyces cerevisiae as eukaryotic model system.

Portrait of Thomas  Brüser

His group studies the mechanism of Tat-dependent transport of proteins across bacterial membranes. Tat transport enables the cells to transport fully folded, often even cofactor-containing and oligomeric proteins across energy-transducing membranes, thereby allowing important cellular functions such as many respiratory pathways and photosynthesis. It is also required for periplasmic maturation of the siderophore pyoverdine that is produced by fluorescent pseudomonads, which became a second research focus of the lab. As the Tat system imposes stress on cytoplasmic membranes, the group is also investigating sensing and signaling of membrane stress by the Psp system.

Portrait of William C Burhans

Bill Burhans trained as a mammalian cell biologist at the University of Vermont (USA) and the Roche Institute of Molecular Biology (USA). He is an Associate Member in the Molecular and Cellular Biology Department at Roswell Park Cancer Institute in Buffalo, New York (USA) and Associate Professor of Oncology in the Roswell Park Division of SUNY@Buffalo. His laboratory employs the budding yeast model organism S. cerevisiae and cultured mammalian cells to model early events in neoplastic transformation that are also relevant to aging. Research in the Burhans laboratory is currently focused on addressing how conserved metabolic pathways impact cell cycle regulation and DNA replication.

Portrait of Sabrina Büttner

Editor's portrait and information coming up soon.

Portrait of Richard Calderone

Editor's portrait and information coming up soon.

Portrait of Allan  Caplan

Editor's portrait and information coming up soon.

Portrait of Yunrong Chai

Bacterial biofilms are medically and environmentally significant. Research in Dr. Chai’s lab focuses on understanding fundamental mechanisms controlling bacterial biofilm formation and the role of beneficial biofilms in bacteria-host interactions, by using Bacillus subtilis and other related Bacilli species as model systems. The lab is also interested in exploring inhibitory mechanisms targeting key processes during bacterial biofilm development.

Portrait of Paul  Chambers

Editor's portrait and information coming up soon.

Portrait of Michael  Chang

Michael Chang is an Assistant Professor at the European Research Institute for the Biology of Ageing within the University of Groningen and the University Medical Center Groningen (The Netherlands). His research group uses the budding yeast Saccharomyces cerevisiae to study telomere maintenance and genome integrity as it relates to cancer and aging.

Portrait of Josep Clotet

His research focuses on the elucidation of the multiplicity role and the apparent redundancy of CDKs in the control of eukaryotic cell cycle. His group is currently involved in the study of mechanisms that modulate cyclins stability and how nutrients control the cell cycle molecular machinery.

Portrait of Charles  Cole

Editor's portrait and information coming up soon.

Portrait of Alejandro  Colman-Lerner

In his lab, S. cerevisiae is used as a model system to focus on signal transduction and cell fate determination from a systems biology viewpoint, integrating single cell experiments with mathematical modeling. In particular, his group studies the mating pheromone response and its interactions with the high osmolarity response pathway and the cell cycle machinery.

Portrait of Katrina F   Cooper

Katrina Cooper earned her D. Phil. from Oxford University (UK) and pursued post-doctoral studies at the Fox Chase Cancer Center in Philadelphia (USA). Research in her laboratory focuses on deciphering how cells translate external stress signals into the appropriate molecular response. To this end, she is focusing on the molecular mechanisms that trigger stress-induced mitochondrial fission and programmed cell death using both budding yeast and mouse models.

Portrait of Manuela  Côrte-Real

She has been particularly interested on the role of mitochondria in yeast apoptosis induced by acetic acid and ceramide with special focus on the elucidation of mechanisms underlying mitochondrial outer membrane permeabilization and release of apoptogenic factors. She has also been exploiting the yeast heterologous expression system to study regulation of mammalian apoptosis components, such as members of the Bcl-2 family. More recently, she has been investigating the role of the vacuole and its crosstalk with mitochondria during apoptosis. To validate their findings with the yeast model system, mammalian cell lines have been used.

Portrait of Vítor  Costa

Vítor Costa is currently a professor at the University of Porto (Portugal). His research focuses on signalling pathways that control mitochondrial function and redox homeostasis in the yeast Saccharomyces cerevisiae. His group is currently interested on the role of sphingolipid signalling in cell death under stress conditions and during cell ageing.

Portrait of Christophe Cullin

His lab’s goal is to understand the molecular characteristics of toxic amyloids. To answer this challenging question, his group expressed in yeast different amyloid peptides such as Aß and combined various in vivo approaches to characterize mutations involved in amyloid toxicity. His lab has also developed "structure-toxicity" approaches based on purified amyloid mutants selected for their toxicity.

Portrait of Pascale  Daran-Lapujade

The goals of her research are to investigate the physiology of industrial microorganisms, to unravel the molecular mechanisms that drive their response to diverse environmental stimuli and to identify the evolutionary circumstances that have shaped their genomes. Although part of the knowledge generated is used to modify microbes and improve their properties for industrially-relevant applications, her research has contributed to the understanding of fundamental aspects of microbial physiology and metabolism, and more specifically of yeasts. One of the major strengths and field of expertise of her group resides in the implementation of advanced cultivation tools that enable tightly controlled and highly reproducible growth of microbes, like the chemostat and retentostat systems. These tools allow the achievement of unique and highly relevant physiological status that cannot be reached by any standard cultivation tool (i.e. shake-flask and plates).

Portrait of Biswadip Das

Biswadip Das is an Associate Professor at the Department of Life Science and Biotechnology at Jadavpur University (India). His research interests are focused on quality control of eukaryotic gene expression, including mRNA decay and surveillance.

Portrait of Guenther  Daum

His laboratory is working on the biogenesis and maintenance of biological membranes and the assembly of lipids into organelle membranes using yeast as a well-established experimental system. His group combines biochemical, molecular and cell biological methods to address problems of lipid metabolism, lipid depot formation and membrane biogenesis. Specific aspects being studied currently in his laboratory are (i) assembly and homeostasis of phosphatidylethanolamine in yeast organelle membranes, (ii) neutral lipid storage in lipid particles/droplets and mobilization of these depots with emphasis on the involvement of lipases and hydrolases, and (iii) characterization of organelle membranes from the industrial yeast Pichia pastoris.

Portrait of Ian  Dawes

His research interests are in the fields of regulation of gene expression during cell development and in response to stress or environmental changes. He has used a combination of biochemical, genetic and genomic approaches to study cellular redox homeostasis, responses to oxidative stress, nutritional changes, ageing and how cells respond to anti-tumour drugs. He has used the powerful modern techniques of functional genomics to study how cells regulate sets of pathways in the cell, and how the control systems interact with each other.

Portrait of Jesús  de la Cruz

Jesus de la Cruz is currently Professor at the Department of Genetics, University of Seville (Spain) and Group Leader at the Institute of Biomedicine of Seville (IBIS). His laboratory works on understanding the mechanism of ribosome biogenesis in eukaryotic cells using the yeast Saccharomyces cerevisiae as model organism. His group is currently focused on the functional analysis of RNA helicases that contribute to yeast ribosome biogenesis. In addition, his laboratory is interested in understanding the precise role of ribosomal proteins in ribosomal subunit assembly.

Portrait of Marcel  Deponte

Marcel Deponte is currently working as an independent group leader and at the Department of Parasitology at the Ruprecht-Karls University in Heidelberg (Germany). He is interested in comparative protein biochemistry with an emphasis on enzymology and molecular parasitology. His group compares the mechanisms of redox enzymes as well as mitochondrial protein import machineries from yeast, the malaria parasite Plasmodium falciparum and the kinetoplastid parasite Leishmania tarentolae.

Portrait of Sylvie  Dequin

Her research focuses on genomics, metabolism and metabolic engineering of industrial yeasts. She is interested in elucidating the bases of genetic and metabolic diversity, the mechanisms involved in the adaptation of yeast to their environment and in developing metabolic engineering strategies to improve the potential of yeast in biotechnologies, particularly wine fermentation.

Portrait of Rodney Devenish

His laboratory is interested in organelle turnover, with particular focus on the nucleus and mitochondria in the yeast S. cerevisiae. In addition, his group explores autophagic responses of mammalian cells to bacterial infection.

Portrait of Jean-Paul  di Rago

Editor's portrait and information coming up soon.

Portrait of Martin B.  Dickman

He received his B.S. degree in Horticulture and his M.S. and Ph.D. degrees in Plant Pathology/Biochemistry from the University of Hawaii (USA). After a postdoctoral fellowship at the Institute of Biological Chemistry at Washington State University (USA), he joined the faculty at the University of Nebraska (USA)in 1987 as an assistant professor, was promoted to full professor in 1997, and was named the Charles Bessey Professor of Plant Pathology. Currently, he is the Christine Richardson Professor and Director of the Borlaug Center at Texas A&M University (USA). The Dickman lab has a long standing interest in plant-fungal interactions with respect to cell death control. His primary emphasis is on programmed cell death (apoptosis/autophagy) and the extent to which parallels exist between plant and animal cell death systems. The overall goals of his studies are to understand the mechanisms that regulate programmed cell death in plants and microbial pathogens and to generate transgenic plants with novel mechanisms of pathogen resistance.

Portrait of Jürgen Dohmen

His lab’s research focuses on the regulation and quality control of proteins by selective degradation, for which his group uses Saccharomyces cerevisiae as a model system. Specific topics include the role of chaperones in ubiquitin-dependent proteolytic quality control, the regulation of proteins by sumoylation and SUMO-dependent proteolytic targeting, ubiquitin-dependent and ubiquitin-independent mechanisms in the control of polyamine homeostasis, as well as the regulation and biogenesis of the proteasome, the central player in most of these processes.

Portrait of Diana M.  Downs

The work in Dr. Downs‘ laboratory addresses metabolic integration using a microbial model system. Her team is interested in metabolic regulation including robustness, pathway recruitment and endogenous metabolic stress and its control.

Portrait of Tobias Eisenberg

He is interested in the crosstalk between autophagy, aging and metabolism. Autophagy, a major cellular degradation pathway with often cytoprotective properties, has evolved as one of the primordial anti-aging mechanisms in various organisms. Both the aging process and autophagy are controlled by nutrient responsive signaling, but the mechanistic basis of regulation through metabolic circuitries remains largely elusive.

Portrait of Hanna  Engelberg-Kulka

In 1996, her group discovered the first prokaryotic programmed cell death (PCD) pathway: E.coli mazEF, which is the first described chromosomal toxin-antitoxin system. Since then, her lab has studied its genetic, biochemical, structural, regulatory and physiological properties, and determined the bacterial network participating in mazEF-mediated death. Her group also found that this PCD system represents a population phenomenon, requiring a new biological molecule, the Extracellular Death Factor (EDF), which is a signaling quorum sensing (QS) communication peptide acting between bacteria. EDF affects the activity of the toxin MazF and it may be a basis for a new class of antibiotic. In addition, her lab uncovered a novel translation machinery (STM) generated by the toxin MazF under stressful conditions. It compose leaderless mRNAs and deficient ribosomes (lacking the anti Shine-Dalgarno region in the 16S rRNA), and is responsible for the production of proteins involved in bacterial cell death. More recently, her group discovered a second E.coli PCD system, participating in an apoptotic–like death (ALD) pathway. It is inhibited by the non-apoptotic death system mazEF. In summary, her lab is currently studying : A) The steps involved in each of the E.coli PCD pathways and the interplay between the two; B) The novel stress- induced translation machinery (STM); and C) The QS peptides EDF of E.coli and other bacteria, their mode of action, and the mechanism of their generation.

Portrait of Birthe Fahrenkrog

Birthe Fahrenkrog is a professor at the Institute of Molecular Biology and Medicine at the Université Libre de Bruxelles (Belgium). Her lab has been identifying apoptotic regulators conserved in yeast and is engaged in their characterization. At the same time, she is interested in epigenetic regulation of apoptotic cell death in S. cerevisiae and humans.

Portrait of Nicolas  Fasel

Nicolas Fasel is full professor at the Faculty of Biology and Medicine of the University of Lausanne (Switzerland). His research is centered around the function of the cysteine protease metacaspase in the cell death of the human Leishmania parasites. Recently, his group reported the important role of a virus present in Leishmania parasites as a factor implicated in the exacerbation of the infection in some forms of leishmaniases.

Portrait of Mathias  Faure

He is a full Professor in immunology at the University Claude Bernard Lyon 1. His research team is within the International Center for Infectiology Research (CIRI) located in Lyon and affiliated to Inserm, CNRS, ENS-Lyon and UCB-Lyon1. The team is interested by deciphering the molecular regulation of autophagy, and the role of autophagy in the context of viral and bacterial infections in regards of pathogen life, cellular response, immune response, and development of intestinal-associated immunopathologies.

Portrait of Mark C  Field

Mark Field is full professor at the Department of Biological Chemistry and Drug Discovery at the University of Dundee (UK). He works primarily on the cell biology of trypanosomes, with specific interests in intracellular trafficking, protein processing and events at the nuclear envelope controlling gene expression. He also has interests in evolutionary biology and specifically the reconstruction of evolutionary histories of protein families involved in eukaryotic organelle biogenesis.

Portrait of Jean-Marie Francois

Jean Marie Francois obtained his PhD from the University of Louvain (Belgium). He is full professor in Molecular Physiology, Industrial Microbiology and Nanobiotechnology at the National Institute of Applied Sciences, University of Toulouse (France). His research activity concerns integrated physiology and functional genomics in microbial systems, with a specific focus on carbon and energy metabolism in yeast and filamentous fungi. Another major topic of his group is now focused towards synthetic biology with the aim at exploiting biomass resources to produce chemical synthon through a synthetic microbial metabolism refactoring approach.

Portrait of Teresa  Frisan

The laboratory of Teresa Frisan is interested in understanding the role of bacterial genotoxins in acute and chronic bacterial infection. Bacterial genotoxins are relative new members of bacterial effectors, which cause DNA damage to the host cells. However, their role in the context of infections is still poorly characterized. Her group’s research activity is devoted to the development of in vivo, in vitro and ex vivo models to address this complex question. The scientific interests cover several aspects of the biology of this toxin family: from internalization to remodeling of the host microenvironment at cellular, tissue and systemic levels. Specifically, her lab is interested in assessing whether the toxins’ DANN-damaging activity and ability to promote genomic instability may be associated with tumor initiation/progression in persistent infections.

Portrait of Kai-Uwe Fröhlich

Editor's portrait and information coming up soon.

Portrait of Johannes Gach

His research is mainly focused on the characterization of HIV antibodies and their effector functions including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). He is also very interested in the development of high throughput screening platforms to evaluate antibody immune responses in vaccinated or HIV-infected individuals.

Portrait of Ali  Gargouri

Besides hydrolytic enzymes and fungal biotechnology, his lab focuses on the study of yeast apoptosis mediated by the overexpression of p53 human gene. His group also investigates the molecular status and the epigenetics of cancer genes in Tunisian patients.

Portrait of Sergio  Giannattasio

His group at the Institute of Biomembranes and Bioenergetics of the National Research Council (Bari, Italy) uses the yeast Saccharomyces cerevisiae as a model organism to study cell death and stress response to identify new regulatory compounds/processes. He is interested in mitochondrial signaling and metabolism that regulate cell life and death decisions and in the use of yeast to study the mechanisms of action of cancer susceptibility genes.

Portrait of Paola  Goffrini

Paola Goffrini is a researcher at the Department of Life Sciences at the University of Parma (Italy). She has carried out research in the fields of yeast genetics and molecular biology with particular attention being paid to the study of the nucleo-mitochondrial relationship, on which many cellular processes depend. More recently, her research has aimed at defining yeast as a model system for approaching the molecular bases of human mitochondrial disorders as well as the connection between aging and mitochondrial dysfunction.

Portrait of Gustavo H Goldmann

After finishing his undergraduate studies in Biology at the Universidade Federal do Rio de Janeiro (Brazil ,1983), he went on to obtain his master’s degree in Microbiology at the Universidade de São Paulo (Brazil, 1988) and his PhD in Molecular Biology at the University of Gent (Belgium, 1993). He was a postdoc in Cellular Biology at the University of Medicine and Dentistry of New Jersey (USA, 1993-1994) and a Visiting Professor at the Universidade do Minho (Portugal). He is currently a Professor of Molecular Biology at the Universidade de São Paulo, Researcher 1A, National Council of Research and Development (CNPq) (Brazil) and an expert in molecular genetics of filamentous fungi.

Portrait of Pierre  Golstein

Pierre Golstein first studied mechanisms of T cell mediated cytotoxicity, demonstrating the existence of CTLA-1 and CTLA-3 (Granzymes B et A, respectively), in the perforin-granzyme pathway of cytotoxicity, and identifying the Fas pathway of cytotoxicity, also leading to the cloning of the Fas Ligand. By-products of this research were CTLA-4 and CTLA-8 (Interleukin-17), now studied by others in a therapeutic perspective. Pierre Golstein then shifted to mechanisms of programmed cell death per se, studying first interdigital cell death in the mouse embryo, then focussing on developmental cell death in the protist Dictyostelium discoideum. Dictyostelium is an excellent genetically tractable model organism for the study of this death, which is being investigated as to its phenomenology and through genetic approaches as to its molecular bases.

Portrait of Joel  Goodman

His lab is interested in the assembly of organelles, especially lipid droplets and peroxisomes. His group wishes to understand the processes by which these organelles receive proteins and lipids, how they communicate with other cellular structures and act in metabolic pathways, how fission and fusion is regulated, and how they segregate during cytokinesis.

Portrait of Gregor Gorkiewicz

Gregor Gorkiewicz is currently a Professor for Medical Microbiome Research and an Associate Professor for Pathology at the Medical University of Graz (Austria). His research is mainly focused on inflammatory and infectious diseases of the gastrointestinal tract and the contribution of the microbiome to these conditions. He is particularly interested in the cross-talk between the microbiome and the mucosal immune system of the host and how the molecular determinants of this interplay lead to disease. At the same time, he is also interested in how these interactions could be exploited for therapeutic applications.

Portrait of Campbell W  Gourlay

The Gourlay lab holds a strong interest in the role that actin plays in the control of homeostatic mechanisms that contribute to healthy ageing. Of particular interest are interactions between actin, mitochondria and signal transduction pathways that are crucial to cellular response to stress. The lab also uses yeast as a model eukaryote to study a number of aspects of cancer biology and the toxicity associated with protein aggregations linked to human disease.

Portrait of Chris  Grant

His research efforts are aimed at understanding the responses of eukaryotic cells to oxidative stress using the yeast Saccharomyces cerevisiae as a model organism. His lab mainly focuses on the regulation of redox homeostasis and how cells regulate gene expression during stress conditions.

Portrait of Michael  Greenwood

His group is interested in the mechanisms by which cells actively protect themselves from stress in order to prevent premature or inappropriate Programmed Cell Death (PCD). His lab’s main strategy is the identification and characterization of human sequences, and their yeast counterparts, that serve to prevent PCD in yeast.

Portrait of José M.  Guillamón

His research is focused on the phenotypic and genotypic analysis of industrial yeasts to understand Saccharomyces cerevisiae adaptation to important industrial fermentative processes such as the elaboration of wine, beer, cider, etc. His lab uses different high-throughput techniques to unravel these adaptation mechanisms to environmental and nutritional changes (temperature, nitrogen availability, vitamins, etc.). A global aim is to correlate genomic features of different yeasts with phenotypic differences of industrial interest. His group is also performing several programs of genetic improvement of industrial yeasts by non-GMO techniques (hybridization, engineering evolution, etc.).

Portrait of Nancy  Guillén

Nancy Guillén is a Research Director at the National Center for Scientific Research (France) and is the head of Cell Biology of Parasitism Unit - INSERM U786. Her research domain concerns the pathogenic process of the parasite Entamoeba histolytica, the agent of human amoebiasis. The project is about host-pathogen interactions with research topics including: comparative genome and transcriptome analysis, molecular and cellular pathophysiology coupled with live cells imaging, cell motility and cytoskeleton.

Portrait of Nishith Gupta

Nishith Gupta studied MS in biotechnology at the Banaras Hindu University (India) and completed his PhD in microbial biochemistry at the University of Leipzig (Germany), followed by postdoctoral research in lipid biochemistry at the National Jewish Medical Research Center in Denver (USA). He then relocated back to Germany and became an independent research group leader at the Humboldt University of Berlin (Germany). His group studies the metabolic interactions between the obligate intracellular parasites (namely Toxoplasma, Eimeria and Plasmodium) and respective host cells. His group has also pioneered the application of optogenetics in infection research, particularly to investigate cyclic nucleotides and calcium signaling cascades in intracellular pathogens, which is not so feasible otherwise when using chemical modulators and probes. The main objectives are to reveal the metabolic determinants and signaling mediators that underlie successful lytic cycle and stage differentiation in these pathogens. His lab uses classical methods of reverse genetics, biochemistry and cell biology in conjunction with contemporary tools of transcriptomics, lipidomics, proteomics, metabolomics and optogenetics.

Portrait of Marie  Hardwick

J. Marie Hardwick, PhD, is a virologist and studies neuronal cell death. Her laboratory has developed yeast to study gene-dependent cell death as a model of cancer and other disorders.

Portrait of Stephen  Hare

Dr. Hare’s research interests lie in bacterial pathogenesis with a particular focus on Neisseria. Using principally biochemistry and structural biology techniques, his lab investigates haemoglobin receptors, iron uptake, bacterial stress response, novel antibiotic targets and secreted effector proteins.

Portrait of Troy Harkness

Editor's portrait and information coming up soon.

Portrait of Jiří  Hašek

His lab’s life imaging microscopy studies on the yeast S. cerevisiae concern the stress-induced rearrangement of the translation machinery and associated regulatory proteins.

Portrait of Jürgen  Heinisch

His research focuses on the genetics, cell biology and physiology of signal transduction pathways in different yeasts (Saccharomyces cerevisiae, Kluyveromyces lactis, Hanseniaspora uvarum). His lab studies the mechanisms of cell wall integrity (CWI) signaling through a conserved MAPK cascade, including the dynamics and mechanics of the CWI sensors within microdomains of the plasma membrane. Moreover, his group is interested in the relation to carbohydrate signaling and central metabolism. Applied aspects, which derive from these subjects for medical and biotechnological use, are within the range of his lab’s interests.

Portrait of Enric  Herrero

His research focuses on the cellular responses to oxidative stress and the mechanisms of redox regulation including the relationship with metal homeostasis, using the yeast Saccharomyces cerevisiae as model.

Portrait of Johannes Herrmann

Johannes Herrmann’s group is studying the biogenesis of mitochondria. His lab has two major interests: one is the oxidative protein folding in the intermembrane space, the other is the synthesis of proteins on mitochondrial ribosomes.

Portrait of Wolf-Dietrich  Heyer

Wolf-Dietrich Heyer maintains a life-long interest in the mechanism and regulation of homologous recombination. His laboratory uses a combination of classical and molecular genetics and biochemistry to elucidate the fundamental mechanisms of homologous recombination and its regulation using the yeast Saccharomyces cerevisiae as a lead model. Further studies in his laboratory aim at validating these insights for the human system and applying these insights in translational studies.

Portrait of Walid A  Houry

His research endeavors are aimed at understanding the role of molecular chaperones and proteases in modulating protein homeostasis under different stress conditions. There are three main projects that his laboratory is currently pursuing. One is on the role of Hsp100/Clp system in cellular stress response, the other one is on the role of the Hsp90-R2TP system that his group discovered in box C/D snoRNP assembly, and the third one is on mapping the total chaperone interaction network. In addition, his lab is also interested in identifying potential therapeutic compounds that can modulate protein homeostasis in the cell.

Portrait of Stanimir S.  Ivanov

Intracellular bacterial pathogens frequently establish and reside within specialized membrane-bound compartments to evade host immune responses. His laboratory uses the human pathogen Legionella pneumophila to elucidate how bacteria manipulate the host to establish and expand their intracellular vacuolar niches. Specifically, his group focuses on the host metabolic regulators critical for niche homeostasis, such as the central metabolic checkpoint kinase MTOR.

Portrait of S. Michal  Jazwinski

Dr. Jazwinski's laboratory studies the genetics of replicative aging and age asymmetry in S. cerevisiae. His research interests include the contribution of interorganelle communication, especially signaling from the mitochondrion to the nucleus, and mitochondrial quality control to yeast aging and longevity. They also encompass the analysis of natural genetic variation in yeast longevity.

Portrait of Antonio  Jiménez-Ruiz

Antonio Jiménez-Ruiz is a full professor at the Systems Biology Department at the University of Alcalá (Spain). His research group is involved in the characterization of apoptosis-like processes in the Leishmania parasite, paying special attention to putative executer/regulator molecules such as the nuclease EndoG. At the same time, his group is actively involved in the design of new drugs able to disrupt protein-protein interactions in specific targets from the parasite.

Portrait of Gary  Jones

His lab is engaged in deciphering the role of chaperones, particularly Hsp70, in prion propagation and other cellular functions. Furthermore, he is interested in prions of lower eukaryotes as well as in DNA repair systems in filamentous fungi.

Portrait of Rupinder  Kaur

Her research is aimed at delineating the strategies that the emerging human opportunistic human fungal pathogen Candida glabrata employs to acquire resistance to antifungal drugs, and survive the hostile environment of a mammalian host.

Portrait of Chang H. Kim

Dr Kim is a Professor of Immunology and the Section Head of Microbiology and Immunology at Purdue University. He has been studying lymphocyte biology and immune regulatory mechanisms for more than two decades. His research group studies the roles of steroid hormones (e.g. retinoic acid), microbial metabolites (short-chain fatty acids), and trafficking receptors in regulation of immune responses and tissue inflammation.

Portrait of Hannah  Klein

The Klein lab studies pathways used for DNA damage avoidance, focusing on regulation of the Rad51 recombinase through the action of DNA translocases and helicases. The lab is also studying the consequences of rNMP misincorporation into DNA and the factors that process the damage as a consequence of this error. The yeast system S. cerevisiae is used as a model for the human disease Aicardi Goutieres syndrome, which arises from defects in processing aberrant nucleic acids.

Portrait of Ahmed  Koc

His laboratory’s research area includes yeast molecular biology and genetics, oxidative stress and antioxidant genes, redox biology, aging and cellular death as well as mitochondrial function.

Portrait of Ralf Kölling

His laboratory is studying protein transport and turnover in the yeast Saccharomyces cerevisiae. His group focuses on the role of ESCRT proteins in cargo recruitment and in the formation of intraluminal vesicles at the late endosome. Also, his lab would like to understand how ESCRT proteins contribute to the regulation of gene expression via the Rim101 pathway.

Portrait of Dimitrios P  Kontoyiannis

Dr Dimitrios P. Kontoyiannis received his medical degree Summa Cum Laude from the National and Kapodistrian University of Athens (Greece). He then did a post-doctoral research fellowship in Infectious Diseases at The University of Texas MD Anderson Cancer Center in Houston (Texas, USA), followed by training in Internal Medicine at Baylor College of Medicine in Houston (Texas, USA) where he served as a Chief Resident. He was subsequently trained as a clinical fellow in Infectious Diseases at Massachusetts General Hospital and obtained a Master in Clinical Sciences from Harvard Medical School in Boston (USA). He spent 3 years at the Whitehead Institute for Biomedical Sciences as a fellow in the Harvard/MIT Clinical Investigators Training Program. He is currently the Frances King Black Endowed Professor and Deputy Head-Research in the Division of Internal Medicine at The University of Texas MD Anderson Cancer Center and adjunct professor at Baylor College of Medicine and University of Houston (USA). His research work is in the area of experimental and clinical mycology, focusing on traditional (mouse) and mini-host (Drosophila) models of infection, antifungal drug resistance, pathogenesis, pharmacology and various aspects of epidemiology, diagnostics and treatment of fungal infections. He is the recipient of several national and institutional awards, has authored over 400 peer-reviewed manuscripts and invited to give over 100 lectures in international conferences and prestigious institutions in US and abroad.

Portrait of Karl  Kuchler

Karl Kuchler received his PhD from the Technical University of Graz (Austria). He took post-doctoral training at the Austrian Academy of Sciences in Salzburg (Austria), at the University of California at Berkeley (USA), and the University of Alberta in Edmonton (Canada). He is currently a Professor of Molecular Genetics at the Medical University of Vienna (Austria). The group has a long-standing interest in fungal infection biology, molecular genetics, as well as host immune signaling at their intersections with molecular mechanisms of antifungal drug resistance. The most recent work addresses the role of chromatin modifications and epigenetic changes in gene regulation during host-pathogen interactions.

Portrait of Ashwani  Kumar

His laboratory is focused on understanding the mycobacterial physiology associated with phenotypic drug tolerance. His team is also interested in understanding the host pathways that are crucial for clearance/control of Mycobacteria inside macrophages.

Portrait of Martin  Kupiec

The Kupiec lab is interested in the mechanisms that guard the integrity of the genome. Our research includes subjects such as DNA repair and recombination, DNA damage checkpoint response and telomere biology.

Portrait of Shin  Kurihara

His interests focus on clarifying the mechanism of the production of bacterial metabolites such as polyamines through elucidation of metabolic and transport systems. Recently, his group is conducting research at the genetic level on metabolism and transport of various metabolites of the dominant human gut bacteria and probiotic bacteria.

Portrait of Jun-Yi  Leu

Jun-Yi Leu is interested in the general principles and underlying molecular mechanisms of evolutionary adaptation and speciation. In addition, he investigates spatial regulation of proteins and structural dynamics of cellular compartments in quiescent cells.

Portrait of Tim  Levine

He is interested in intracellular lipid traffic in yeast. His group has proposed that lipid traffic takes place at membrane contact sites, places where two organelles come into very close contact (10-20 nm) without fusing. S cerevisiae is an excellent model for studying contact sites, as it is one of the few organisms where any of the structural components of contact sites have been identified, allowing their genetic manipulation.

Portrait of Susan W  Liebman

Dr. Liebman’s lab helped establish the field of yeast prions. Her laboratory first showed that chaperones are required for prion propagation, that yeast prions can exist in different variants and that the presence of one prion can promote the appearance of a heterologous prion. Her laboratory is now focused on using yeast as a model system to study protein misfolding diseases.

Portrait of Roland  Lill

Roland Lill, Philipps-Universität Marburg (Germany) is interested in the biosynthesis of iron-sulfur clusters and their insertion into apoproteins in eukaryotic cells. Iron-sulfur proteins play crucial roles in energy metabolism, protein synthesis, DNA replication and repair, and in many central metabolic reactions. Their maturation requires the ISC assembly machinery in mitochondria, and the CIA machinery in the cytosol. Impairment of the biogenesis process is associated with a number of severe diseases.

Portrait of Michael  Lisby

His group studies the spatio-temporal organization of the cellular response to genotoxic stress including DNA repair and checkpoint processes and their roles in maintaining genome integrity using a combined cell biological and genetic approach. Particular areas of interest include the molecular architecture of DNA repair complexes in living cells, the response to eroded telomeres and DNA replication stress, chromosome segregation during mitosis, and the regulation of these processes by post-translational modifications.

Portrait of Andreas Martin  Lisewski

His research concentrates around function and phenotype in bacterial and parasitical stress response systems, with particular emphasis on stress response elements and drug targets within the human malaria parasite.

Portrait of Gianni  Liti

His lab uses the budding yeast S. cerevisiae to dissect the genetic architecture of multiple traits related to ageing and cancer. In all aspects of his group’s research, natural variation in the budding yeast is exploited as a tool for understanding how a phenotype is genetically regulated.

Portrait of Patrick  Lomonte

Patrick Lomonte is a CNRS Research Director. His laboratory is affiliated to the Institut NeuroMyoGene (INMG) located in Lyon at the University Claude Bernard Lyon 1. The team focuses its research on the comprehension of herpesviruses biology, and more particularly on herpes simplex virus 1 (HSV-1) latency establishment and reactivation processes. Using HSV-1 as a model of study, he investigates the role of nuclear domains in the epigenetic regulation of gene expression and chromatin dynamics.

Portrait of Maria Pia  Longhese

Maria Pia Longhese is a full professor of Genetics at the University of Milano-Bicocca (Italy). Her laboratory studies the mechanisms governing the cellular response to DNA damage and telomere homeostasis, using S. cerevisiae as a model organism. Her research mainly focuses on understanding how cells sense, process and repair DNA lesions. At the same time, she investigates the mechanisms that ensure telomere homeostasis and inhibit DNA repair activities at telomeres.

Portrait of Esben  Lorentzen

His lab works on the molecular mechanisms of cilium/flagellum formation using biochemical and structural biology techniques. In particular his group is deciphering how ciliary proteins are trafficked into and out of the cilium organelle via intraflagellar transport (IFT). This research is relevant for our understanding of unicellular eukaryotic organisms such as Chlamydomonas reinhardtii but also of mammalian cells, of which most are now known to be ciliated.

Portrait of Edward J  Louis

His research has focused on genetic variation and genome stability in yeast with a particular interest in the ends of the chromosomes or subtelomeres. This has developed in several directions over the years and has included: reproductive isolation and speciation in yeast, chromosome evolution in yeast, genome stability in various mutant backgrounds, telomeres without telomerase, subtelomeres in parasites, genome dynamics over many time scales, population genomics and phenotypic variation and most recently in the quantitative genetic analysis of complex traits.

Portrait of Carsten  Lüder

Carsten Lüder studied biology an the Eberhard-Karls-University of Tübingen (Germany) and is now professor at the Institute for Medical Microbiology of the Georg-August-University of Göttingen (Germany). His major research interests are pathogen-host interactions with a special emphasis on elucidating mechanisms of how the intracellular model parasite Toxoplasma gondii manipulates its host cells in order to evade host immunity and to ensure establishing a chronic infection within its mammalian host.

Portrait of Paula Ludovico

Ludovico's lab uses the eukaryotic budding yeast model to gain new insights into cell stress response, including cell survival and cell death decisions. Research in her lab is particularly focused on the impact that cell decisions have on ageing and life span. Her group is also investigating the toxic effects of human protein-related diseases. Current projects and interests include mitochondrial bioenergetics and metabolic control of cell death, reactive oxygen species signaling and their relevance for autophagy and cell fate upon stress.

Portrait of Ian Macreadie

Ian Macreadie is an Adjunct Professor of Edith Cowan University (Australia) and an Associate Professor of RMIT University (Australia). His background is in yeast mitochondrial genetics. His 24 years at the Commonwealth Scientific and Industrial Research Organisation (Australia) focused on vaccines, AIDS, malaria, drug resistance and Alzheimer's disease, all using yeast. At RMIT University he continues to utilise yeast as a model organism for the study of human health and disease.

Portrait of Tobias Madl

The research of Tobias Madl and his group focuses on integrated structural biology of signal transduction and metabolism. One of his major interests is the general molecular mechanisms of signal transfer mediated by disordered proteins and the intricate link between their function, regulation and human diseases. To obtain systemic insight into regulatory pathways and for translational studies, they use and develop NMR-based metabolic phenotyping.

Portrait of Stéphen  Manon

Editor's portrait and information coming up soon.

Portrait of Emilia Matallana

Her research is focused on the molecular mechanisms underlying the interplay between metabolic adaptation and oxidative stress in wine yeasts, including the regulation of gene expression at transcriptional and translational levels, the enzymatic and non enzymatic redox defense systems, and the oxidative damage of macromolecular cellular components. All the physiological, biochemical, genetic and environmental factors are taken into account to explain and improve the biotechnological performance of these microorganisms, belonging mainly to Saccharomyces cerevisiae but also to other yeast species, by enhancing their oxidative stress response and longevity. Metabolic engineering in synthetic biology and integrative system biology are also main interest areas where collaborative projects are underway.

Portrait of Diethard  Mattanovich

Diethard Mattanovich is full professor of Microbial Cell Design at the University of Natural Resources and Life Sciences Vienna (Austria). His laboratory focuses on the development and characterization of microbial production organisms for biotechnology. Special emphasis is placed on folding and secretion of recombinant proteins in yeast, and metabolic engineering of bacteria and yeasts to adapt pathways towards production of chemicals of industrial interest. Microbial stress and intracellular transport are main topics of interest. Systems biology methods are applied to study microbial cells at a genome scale level.

Portrait of Andreas Mayer

Andreas Mayer's group uses yeast vacuoles to investigate how the size and copy number of an organelle can be regulated by the cell. Special emphasis lies on the equilibrium of organelle fusion and fission since their equilibrium has profound effects on organelle copy number and size. Furthermore, his lab uses yeast vacuoles, which can be considered as large versions of an acidocalcisome, in order to study aspects of acidocalcisome biogenesis and function.

Portrait of Cristina Mazzoni

She’s an associated professor at the Department of Biology and Biotechnology at the University of Rome "Sapienza" (Italy). She has expertise in yeast genetics and molecular biology. Among her studies, she has shown a relationship between mRNA metabolism and the onset of apoptosis and chronological aging. She has also demonstrated the involvement of yeast caspase in the variation of mitochondrial morphology during the apoptotic process and the role of mitochondrial morphology genes during aging. She currently also uses yeast to study the effect of human gene expression and new uncharacterized molecules on longevity and cell death.

Portrait of Lynn  Megeney

Lynn Megeney is a Senior Scientist at the Ottawa Hospital Research Institute and professor in the Department of Cellular and Molecular Medicine at the University of Ottawa (Ottawa, Canada). The Megeney research group discovered the conserved non-death role of apoptotic proteins and pathways from yeast to mammals. The Megeney group continues to investigate the essential role that caspases/metacaspases play in cell differentiation, adaptation and proteostasis.

Portrait of Jane Mellor

Research in the Mellor lab focuses on all aspects of gene expression in the budding yeast Saccharomyces cerevisiae. Current work focuses on the relationship between transcription, chromatin and RNA fate. Where possible, her group studies post-translational modifications to chromatin, nascent transcription, transcript levels, translation (ribosome profiling) and the proteome in the context of changing environmental or metabolic states.

Portrait of Marc Meneghini

Marc Meneghini earned his Ph.D. at the University of Oregon (USA) studying C. elegans embryonic cell fate patterning before moving to budding yeast as a postdoctoral researcher at the University of California, San Francisco (USA). In his own lab at the University of Toronto (Canada), he studies cell biological, genetic, and epigenetic control of mitonuclear and vacuolar regulation throughout the yeast lifecycle.

Portrait of Rikke Louise  Meyer

Her research combines microbiology and nanoscience in the pursuit of understanding how bacteria attach to abiotic surfaces to form biofilms with high antibiotic tolerance. Her group also develops new approaches to prevent biofilm through application of anti-adhesive polymer coatings, and to more effectively treat biofilm infections through targeted delivery of encapsulated antibiotics.

Portrait of Kevin A  Morano

His group is interested in fundamental aspects of the cell biology of protein chaperones, including protein biogenesis and quality control using Saccharomyces cerevisiae as a model system. His laboratory also studies regulation of the heat shock response as a mechanism to control protein homeostasis via transcriptional regulation of cytoprotective genes.

Portrait of Jeremy  Mottram

Jeremy Mottram is Professor of Molecular and Cellular Parasitology in the Wellcome Trust Centre for Molecular Parasitology at the University of Glasgow (Scotland). His main research interests are in the molecular mechanisms by which Leishmania and trypanosome parasites undergo cellular remodelling during their complex life cycles. The lab's focus is on cell signalling events, in particular the role of protein kinases, and the turnover of proteins and organelles, with a focus on peptidases and autophagy. He has yet to be convinced that protozoan parasites undergo programmed cell death.

Portrait of Andrés Moya

Prof. Moya studied Biology and Philosophy simultaneously at the University of València (Spain), obtaining a PhD in Biology in 1983, and a PhD in Philosophy in 1988. He was Postdoctoral Fellow at the University of California (Davis, USA), and an Invited Professor at the University of California (Irvine, USA). In 1986, he created the Evolutionary Genetics Research Group at the Department of Genetics of the University of València, where he is a Professor of Genetics since 1993. Prof. Moya was the promoter of the Cavanilles Institut of Biodiversity and Evolutionary Biology at the University of València, the Astrobiology Center (CSIC-INTA) and the Public Health Research Center (CSISP), now integrated in the Valencian Region Foundation for the Promotion of Health (FISABIO). Currently, he chairs an Institutional Professorship between FISABIO and the University of València. Prof. Moya is the author of approximately five hundred publications about Genetics, Evolution and the Philosophy of Biology. He is involved in the study of the human microbiome under an evolutionary and system biology perspective. Prof. Moya is a founding member of the European Society for Evolutionary Biology, the Spanish Society of Virology and the Spanish Society of Evolutionary Biology, for which he is the current President. He received the “Ciutat de Barcelona” award (1996), the “Diario Médico” award (2006), the “2012 National Award of Genetics” (2012), the “2013 Lilly Award in Biomedical Research”, and the “Mexico Award in Science and Technology” (2015). He is also fellow of the American Association for the Advancement of Science since 1998.

Portrait of David Mueller

David Mueller’s studies focus on the structure function relationship of the mitochondrial ATP synthase. His studies encompass yeast genetics, molecular, and structural biology including x-ray crystallography. His laboratory also examines the structural basis of drugs and inhibitors binding to the proton channel of the ATP synthase.

Portrait of Douglas  Murray

He is the head of the cellular dynamics project which focusses on the "polyomic" and mathematical analyses of the crosstalk between metabolism and transcription, primarily utilising continuous cultures of brewers' yeast. He also has collaborations analysing similar crosstalk mechanisms in other fungi, cyanobacteria and Escherichia coli. He is particularly interested in periodic temporal events, e.g., the respiratory/metabolic oscillation, where he has played an important role in developing the field.

Portrait of Plácido  Navas Lloret

Plácido Navas studied at the University of Seville (Spain) and Purdue University (Indiana, USA). He is currently a member of the Centre for Biomedical Network Research on Rare Diseases (CIBERER) and mainly involved in mitochondrial pathology. His focus is on the regulation of coenzyme Q biosynthesis complex and its role in the assembly and efficiency of respiratory complexes. He is interested in the role of bioenergetics in both health and life span, and the connection of coenzyme Q biosynthesis pathway and mitophagy.

Portrait of Corey  Nislow

His lab is focused on developing and applying genomic technologies to investigate the nature of gene-drug interactions. Some of his group’s current projects include: massively parallel identification of drug targets in Saccharomyces and Candida, screening transposon libraries of large clinical microbe collections for virulence determinants, and understanding how chromatin structure influences gene expression in diverse environments.

Portrait of Torsten  Ochsenreiter

He is interested in understanding mitochondrial genome maintenance in Trypanosomes. His lab uses a combination of molecular biology, biochemistry and super resolution microscopy approaches to address the replication and segregation of the spectacular complex kineotplast DNA in this single-celled parasite.

Portrait of Marco R.  Oggioni

He has two main areas of interest. (i) Analysis of virulence mechanisms of Streptococcus pneumoniae, by use of genomic tools, study of microbial physiology, set up of novel in vitro models including biofilms and in vivo infection models. The main scope is the recognition of specific phases characterising microbial physiology during infection with the aim of identification of novel drug targets. In this context he has focused his attention on carbon metabolism of the bacterium, both in vitro and within the host, with the idea that the "behaviour" of the bacterium is largely influenced by their metabolism and that nutrient availability in different niches within the host govern important aspects in host pathogen interaction. Interaction with engineers and mathematicians expert in complex models has added interdisciplinary aspects to his research. (ii) Development and validation of innovative tools and protocols for molecular diagnostics of microbial infections including molecular drug susceptibility testing. He has been involved for years in design of primer probe based diagnostic approaches, based initially on PCR and later on arrays and real time PCR. Part of this work included involvement in characterisation of molecular mechanisms of drug resistance, including work on mutations in mycobacteria, target substitutions in staphylococci, efflux pumps in pneumococci and staphylococci and the characterization of mobile elements more in general. Most recently he has investigated biocide resistance mechanism in staphylococci and microbial species of interest for the food chain, with the aim to elucidate possible impact of biocide use on antimicrobial drug resistance.

Portrait of Yoshikazu Ohya

Yoshi Ohya is a Professor at the Department of Integrated Biosciences, Graduate School of Frontier Sciences at The University of Tokyo (Japan). His current research focuses on systems biology based on cell imaging, chemical biology, cell cycle checkpoint and regulation of cell wall synthesis. He uses Saccharomyces cerevisiae as a model organism.

Portrait of Koji  Okamoto

His esearch focuses on (1) mitochondrial biogenesis and turnover, (2) mitochondrial dynamics, and (3) mitochondria-autophagy crosstalk in the budding yeast Saccharomyces cerevisiae.

Portrait of Heinz D  Osiewacz

Heinz D. Osiewacz is a professor at the Institute for Molecular Biosciences at the Johann Wolfgang Goethe University in Frankfurt/ Main (Germany). Using the fungal model systems Saccharomyces cerevisiae and Podospora anserina his group investigates the molecular basis of organism aging with special emphasis on the role of mitochondria. His lab’s studies have led to the demonstration of an impact of various molecular pathways like apoptosis, autophagy, proteostasis, mitochondrial dynamics, and mtDNA instability on aging and lifespan control.

Portrait of Martin Ott

His group’s research is focused on the synthesis and assembly of the mitochondrially encoded proteins. Defects in the expression of mitochondrial genes can cause or influence many human diseases including cancer, aging and mitochondrial disorders. Hi slab employs baker´s yeast to study the molecular mechanisms underlying mitochondrial biogenesis and to unravel how problems in these processes impact physiology.

Portrait of Marc Ouellette

His research program is about molecular and cellular responses to drugs. His laboratory uses holistic genomic approaches for studying drug-pathogen interactions in the parasite Leishmania and in the bacterial pneumococcus.

Portrait of Tiago Outeiro

His research interests are focused on the understanding of the molecular mechanisms that lead to neurodegeneration in diseases such as Parkinson's, Huntington's, or Alzheimer's disease. These diseases are intimately associated with protein misfolding and aggregation in specific regions of the brain. Because the molecular pathways involved in protein homeostasis are highly conserved, his group employs a wide variety of model organisms, from the simple but powerful budding yeast to mammalian cell culture and mice, to study the origin of the problems.

Portrait of Zdena  Palkova

Editor's portrait and information coming up soon.

Portrait of Hay-Oak  Park

Her lab investigates how cell polarity and asymmetry are established using budding yeast as a model organism. Her group’s current projects focus on a GTPase signaling pathway involved in polarity establishment; assembly and asymmetrical positioning of a macromolecular complex that specifies a growth site; development of mathematical modeling and empirical testing of morphogenesis; and role of small GTPases in the oxidative stress response and cell death.

Portrait of Graham D Pavitt

Editor's portrait and information coming up soon.

Portrait of Brigitte Pertschy

Brigitte Pertschy is a group leader at the Institute for Molecular Biosiences at the University of Graz (Austria). Her lab works on the synthesis pathway of eukaryotic ribosomes using yeast as a model organism. A current research focus is the characterization of the path of ribosomal proteins from their site of synthesis in the cytoplasm to their ribosome assembly site in the nucleus. In addition, the lab investigates the function of several non-ribosomal assembly factors in ribosome biogenesis.

Portrait of Dina  Petranovic

Her group’s research interest is primarily on yeast S. cerevisiae cell death and aging. Her lab combines methods of molecular and cell biology, biochemistry, bioinformatics and systems biology (including omics and modeling) with the scope to study how cells regulate aging and death pathways and how these pathways are related to proteostasis (proteome homeostasis).

Portrait of Uroš  Petrovič

The focus of his research at the Jožef Stefan Institute in Ljubljana (Slovenia) has been the use of Saccharomyces cerevisiae as a model system to study diverse processes such as lipid metabolism, membrane homeostasis, and neurotoxicity. His laboratory has also been applying novel functional genomics approaches to study yeast-based biotechnologies.

Portrait of Simonetta Piatti

Her laboratory studies the mechanisms controlling mitotic progression and cell division using the budding yeast S. cerevisiae as a model organism. Her group is mainly interested at understanding how mitotic processes are regulated in order to preserve genome stability and prevent the occurrence of aneuploidy. Since cytokinesis defects have been lately emerging as a major source of aneuploidy, her lab is studying how cytokinesis is regulated during the cell cycle and how it is coupled to nuclear division. In this context her group is focusing its attention on the regulation of the “mitotic exit network”, which triggers mitotic exit, and of the cytoskeletal proteins septins, which in yeast are essential for cytokinesis. Another longstanding interest of the lab is how the spindle assembly checkpoint ensures balanced chromosome segregation. Her group has identified and is characterizing factors that allow mitotic slippage when the checkpoint is not satisfied.

Portrait of Alena Pichova

Her research focuses on cellular and molecular mechanisms of yeast aging and apoptosis, especially on the relationship between mitochondrial morphology and the activity in cells of different physiological state and age as well as on yeast morphology.

Portrait of Stephane  Picot

He is Professor of Medicine, Head of the Institute of Parasitology and Medical Mycology at the Lyon University Hospital (France) and team leader of the Malaria Research Unit at the National Center for Scientific Research (CNRS UMR 5246, France). He is also President of the Chemotherapy against Parasite and Fungi (CaPF) network. He was the first to describe malaria parasite apoptosis and Plasmodium metacaspase pathways. He translated basic research to clinical trials and used anti-apoptotic drugs in patients suffering severe malaria in Africa. He has extensive experience of field clinical work in Africa, Asia and South America. He is both biologist and clinician acting at outpatient clinic for travel prevention and diseases.

Portrait of Peter Polcic

He is interested in transport processes at mitochondrial membranes. His lab uses yeast as a tool to study the permeabilization of mitochondrial membranes caused by mammalian proteins of the Bcl-2 family.

Portrait of Michael  Polymenis

His group`s research goal is to understand what determines when cells begin a new round of cell division. Knowing which cellular pathways, and how these pathways, affect the machinery of cell division will allow modulations of cell proliferation, because such processes dictate how fast cells multiply.

Portrait of Liza Pon

Mitochondria have emerged as aging determinants through their functions in central metabolism and oxidative stress. The Pon laboratory uses the budding yeast Saccharomyces cerevisae to study mitochondrial motility and dynamics, mechanisms underlying mitochondrial quality control, inheritance and interactions with other organelles, and how these processes affect replicative lifespan, cellular healthspan and cell cycle progression.

Portrait of Francesc  Posas

Editor's portrait and information coming up soon.

Portrait of Claudina Pousada

Claudina Rodrigues-Pousada is Full Professor and head of the genomics and stress laboratory at the Instituto de Tecnologia Química Biológica António Xavier (Universidade Nova de Lisboa, Portugal). Her research interests are focused on the mechanisms used by the cells to regulate gene expression when confronted with several environmental cues in order to maintain proper homeostatic control. Her group has discovered a family of transcription factors formed by 8 members belonging to the bZIP structure, the Yap family. Her laboratory is therefore interested in understanding how these transcription factors activate the basal machinery of transcription and how they are regulated under several environmental stresses such as arsenic compounds, high levels of iron and oxidative stress. Her group uses modern global techniques to analyse the targets of those transcription factors as to integrate them in the several metabolic pathways.

Portrait of Ted  Powers

Editor's portrait and information coming up soon.

Portrait of Sergi  Puig

His primary focus of interest consists on deciphering the mechanisms that the budding yeast Saccharomyces cerevisiae utilizes to properly respond to the deficiency of iron, an essential micronutrient for all eukaryotes. They study in detail the post-transcriptional regulation of gene expression that leads to a global metabolic reprogramming when iron is scarce. Furthermore, yeast cells are also used as a biotechnological tool for the development of novel strategies to prevent and treat iron deficiency anemia and to improve the properties of industrial yeast strains.

Portrait of Satish  Raina

His main interests are: Catalysis of protein folding by PPIases and Dsb Proteins; transcriptional regulation, heat shock response and regulation of cell envelope stress by RpoE sigma factor and non-coding sRNAs; regulated assembly of lipopolysaccharides

Portrait of Doron  Rapaport

His group investigates the molecular mechanisms by which mitochondrial outer membrane proteins are targeted to mitochondria, inserted into the outer membrane and assembled into functional complexes. He further studies the homeostasis of mitochondrial lipids and their importance for the aforementioned processes. For these studies the group uses both yeast and mammalian tissue cultures as experimental systems.

Portrait of Ulrich  Rass

His group uses Saccharomyces cerevisiae as a model to study eukaryotic DNA replication and repair mechanisms maintaining genome stability. Focal areas include DNA double-strand break repair and replication fork recovery under replication stress conditions. Using CRISPR/Cas9-mediated genome editing, the group translates mechanistic insight directly from yeast to human studies, exploring potential biomedical implications in cancer cell models.

Portrait of Fulvio  Reggiori

Fulvio Reggiori is an Associate Professor at the Department of Cell Biology of the University Medical Center Utrecht (The Netherlands). He is investigating the regulation and mechanism of autophagy using the yeast Saccharomyces cerevisiae as a model organism. His laboratory is also studying the autophagy-pathogen interaction mostly in the context of viral infections.

Portrait of Andreas  Reichert

His lab aims to elucidate the molecular mechanisms governing mitochondrial quality control focusing on mitophagy and mitochondrial dynamics. How these processes are linked to the aging process and the pathogenesis of numerous human disorders is a major interest of his research. Another focus is to understand the molecular mechanisms that shape the inner mitochondrial membrane, particularly, cristae and crista junctions and their importance in cellular viability.

Portrait of Klaus  Richter

Editor's portrait and information coming up soon.

Portrait of Patrick  Rockenfeller

Patrick Rockenfeller´s research focuses on the identification of lipotoxic cell death and autophagy pathways in yeast. He is particularly interested in the lipid species and mechanisms which induce/regulate cell death and/or autophagy.

Portrait of Andrew J Roe

The major focus of the work in the Roe lab is the model organism, Escherichia coli, which is very diverse and can exist as both a commensal or a pathogen, causing serious infections. As E. coli is such a tractable organism, his group utilizes a wide variety of methods, ranging from microbiology and molecular biology, via biochemistry, to structural biology to aid our understanding of how E. coli pathotypes colonise specific niches within the host.

Portrait of Luis  Rokeach

Luis Rokeach is a professor at the Department of Biochemistry and Molecular Medicine at Université de Montréal (Canada). His group pioneered Schizosaccharomyces pombe as a model to study chronological aging, described calnexin as regulator of apoptosis, and discovered the Cin epigenetic state in fission yeast. Currently, his research focuses on the pathways of apoptosis regulated by calnexin, the interplay between apoptosis and autophagy in the regulation of cell death and longevity, and in elucidating the pathways leading to and regulated by the Cin epigenetic state.

Portrait of Frank  Rosenzweig

Research in the Rosenzweig lab is aimed at illuminating the evolution of complex traits that augment biodiversity, control cell lifespan and drive major transitions in the history of life. His lab’s goals are to understand how changes in genome architecture alter global patterns of gene expression, whether such changes explain the physiology and behavior of novel genotypes, and the extent to which adaptation is shaped by trade-offs and constraints. Because all major evolutionary transitions require cooperative behavior, his group is especially keen to discover genetic changes that promote this trait. The lab’s approach to these goals is experimental evolutionary genomics using as models the bacteria Escherichia coli and Bdellovibrio bacteriovorus, the Baker’s yeast Saccharomyces cerevisiae and the unicellular alga, Chlamydomonas reinhardtii.

Portrait of Christoph Ruckenstuhl

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Portrait of Thomas  Rudel

The group of Thomas Rudel investigates pathogenicity mechanisms of different microorganisms, including the major human pathogens Chlamydia, Neisseria gonorrhoeae and Staphylococcus aureus. His research focuses on the subversion of innate immune signaling by these pathogens and on the interface of infection and cancer.

Portrait of Isabel  Sá-Correia

Isabel Sá-Correia is Full Professor and Head of the Biological Sciences Research Group at the Instituto Superior Técnico (IST), Universidade de Lisboa (Lisbon, Portugal). Her research interests are in the fields of Molecular and Cellular Microbiology, Functional and Comparative Genomics and Bioinformatics, and Microbial Biotechnology. In the field of Yeast Toxicogenomics, a molecular systems biology approach is used to obtain mechanistic insights and a genome-wide view on the responses to chemical compounds relevant in Environmental Health, Pharmacology and Biotechnology and to characterize new signalling pathways and gene regulatory networks under chemical stress. In the field of molecular and cellular biology of yeasts, her research is focused on: i) the regulation of gene and genomic expression under stress; ii) transmembrane transport, in particular the functional analysis of drug/xenobiotic efflux pumps of the MFS and ABC superfamily and their role in cell defense, multidrug resistance (MDR) and impact in industrial and environmental biotecnology.

Portrait of Isabelle Sagot

Her lab is studying the remodeling of cellular machineries (the actin and tubulin cytoskeletons, the proteasome, the mitochondria, etc.) that occur upon transition from proliferation to quiescence in S. cerevisiae, S. pombe and human cells. Her group also uses quiescent cells-specific cellular reorganizations as tools to understand how quiescent cells do survive and rapidly give rise to a rejuvenated progeny as well as to decipher the cascade of molecular switches that control quiescence exit.

Portrait of Pedro A. San-Segundo

His current research is mainly focused on the meiotic recombination checkpoint in the budding yeast Saccharomyces cerevisiae. This surveillance mechanism is triggered by defects in chromosome synapsis and/or meiotic recombination and blocks or delays meiotic cell cycle progression to prevent aberrant chromosome segregation and the formation of aneuploid gametes. His group investigates this checkpoint pathway at several levels (sensors, adaptors, effectors and targets) with particular interest in deciphering the functional contribution of chromatin modifications to this evolutionarily-conserved meiotic quality control mechanism.

Portrait of Raffael Schaffrath

Using microbial toxins (diphtheria toxin, tRNase ribotoxins) and yeasts as models for organismic competition, the Schaffrath lab focuses on cell growth control in response to antifungal stress. Among others, his group studies mRNA translation-relevant protein and tRNA modification pathways that are hijacked by these toxins.

Portrait of Stefan Schild

Dr. Schilds main interests lie in bacterial pathogenesis and bacterial adaptation in response to environmental and host conditions as well as in biogenesis and physiological roles of bacterial membrane vesicles.

Portrait of Maria  Segovia

Maria Segovia studied at the Complutense University Madrid (Spain) where she obtained her PhD in biology. She has worked at Queen’s University Belfast (UK) and at the University of Málaga (Spain) where she is currently lecturer in Ecology at the Department of Ecology and Geology. Her field of expertise and research is focused on the molecular physiology of unicellular algae related to environmental stress, i.e. cell viability and death, oxidative stress, as well as DNA and photosynthesis damage and repair.

Portrait of Fedor  Severin

His lab studies the links between mitochondrial dynamics, reactive oxygen species formation, stress response, and the cell cycle. His group’s most recent research interest is to apply yeast to study the mechanism of action of mitochondria-targeted antioxidants.

Portrait of Amir  Sharon

His research focuses on the study of programmed cell death (PCD) in yeast and filamentous fungi focusing on PCD networks in fungi and on the role of PCD in fungal pathogenesis.

Portrait of David Shore

David Shore studied the energetics of DNA bending and twisting as a PhD student before beginning work on gene silencing in yeast as a postdoctoral fellow. His lab, first at Columbia University in New York City (USA), and since 1996 at the University of Geneva (Switzerland), where he is Professor of Molecular Biology, has worked mostly on telomere biology (telomere length regulation and telomere « capping »). The Shore lab has more recently begun to focus on the transcriptional regulatory network controlling ribosomal protein gene expression as a model system to study the relationship between promoter architecture and transcriptional output, as well as mechanisms by which growth and stress signals modulate transcription.

Portrait of Wolfram  Siede

His laboratory is mainly interested in DNA repair, mutagenesis, cell cycle regulation, radiation effects and anti-cancer drug characterization in Saccharomyces cerevisiae.

Portrait of Himanshu Sinha

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Portrait of Barbara S.  Sixt

Barbara S. Sixt is interested in the role of programmed cell death in the cell autonomous defense against the obligate intracellular pathogen Chlamydia. During her PhD work at the University of Vienna (Austria) she studied environmental chlamydiae that naturally infect protozoa or arthropods; including their proteomic and metabolic features, as well as their ability to block host cell death. After completing 3 years of postdoctoral training at Duke University (NC, USA), she is currently affiliated with INSERM U1138 (France). Her most recent research focuses on the application of emerging genetic tools for Chlamydia to identify and characterize bacterial factors that counteract host cell death and other branches of the cell autonomous defense.

Portrait of James Smith

Novel peptide-based antimicrobials are of great interest to his group. Whether ribosomally or non-ribosomally synthesized, these compounds often contain complex structures and systems leading to their production. His research is aimed at understanding the microbial physiology leading to the production of these compounds and the microbial physiology/mechanism of action of how these compounds target microorganisms.

Portrait of Jeffrey S.  Smith

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Portrait of Filipa L. Sousa

She is a researcher at the Department of Ecogenomics and Systems Biology at the University of Vienna (Austria) and focuses on bioenergetics, evolution and metabolism from both a bioinformatics and biochemical point of view.

Portrait of Maria João  Sousa

She is currently a professor at the University of Minho (Portugal). Her main areas of interest have been the cellular and molecular responses of conventional and non-conventional yeast to different environmental stresses or changes, including metabolic adaptation with emphasis on transport systems, mechanisms underlying resistance or induction of cell death. In the last years, she has been particularly interested in the study of yeast apoptotic and necrotic pathways and their regulation using acetic acid and ammonium as death stimuli. She is also interested in the use of yeast as a model system for the study of heterologously expressed mammalian proteins and for the identification of cellular targets of natural compounds and novel synthetic molecules.

Portrait of Christian  Speck

His laboratory is interested in understanding how the eukaryotic replicative helicase MCM2-7 is loaded onto DNA, how it becomes activated during the initiation of eukaryotic DNA replication and how the helicase is integrated into the replication fork. His group uses reconstituted reactions with purified budding yeast proteins to study the assembly and regulation of the DNA replication machine. Work in the human system is geared to identifying inhibitors of DNA replication with potential for anticancer therapy. The lab employs creative biochemical and electron microscopy approaches to discover novel functions and mechanisms during DNA replication.

Portrait of Ulrich  Stelzl

The group of Ulrich Stelzl focuses on the analysis of molecular interaction networks with the aim to understand the dynamics of molecular networks underlying cellular processes related to human disease. Experimental functional genomics techniques, e.g. HTP Y2H screening, are utilized in combination with biochemical, cell biological and computational methods. In combination with mammalian cell culture and in silico work, yeast is used as a model and serves as the main tool for versatile screening approaches.

Portrait of Katja  Straesser

Katja Sträßer studied at the universities of Braunschweig (Germany), Geneva (Switzerland) and Heidelberg (Germany) and at the Salk Institute (La Jolla, USA) and was an independent group leader at the Gene Center of the University of Munich (Germany). Currently she is a full professor at the University of Giessen (Germany). Her research interests focus on the connection between transcription and nuclear mRNA export and how mRNPs are formed cotranscriptionally. A second research direction in the lab is the phosphorylation of ribosomal proteins and its impact on translation. These processes are mainly studied in the model organism S. cerevisiae.

Portrait of Stephen  Sturley

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Portrait of Katsunori Sugimoto

His laboratory is aiming to understand the mechanism of DNA damage response in yeast. His group also studies telomere homeostasis using budding yeast as a model system.

Portrait of Hiroshi Takagi

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Portrait of Kevin Tan

Kevin Tan is an associate professor at the Yong Loo Lin School of Medicine, National University of Singapore (NUS). He obtained his PhD at NUS and pursued his postdoctoral research at The Rockefeller University (USA). His research focuses on understanding cell death mechanisms in parasitic protozoa, with an emphasis on malaria parasites. His group was the first to report on lysosome-mediated cell death in malaria parasites. With a deeper understanding of such mechanisms, he is developing new tools for drug discovery in order to identify novel and effective therapeutics.

Portrait of Fusheng Tang

Among organelles of the yeast cell, vacuoles begin to deteriorate in a very early stage of aging. As such, he is focusing on the contribution of late endosome-vacuolar membrane trafficking to the aging of the yeast cell.

Portrait of Bas Teusink

The Teusink lab investigates the design principles of cellular physiology and metabolism. The main drive is to understand not only the mechanisms, but also the reason why these mechanisms were selected, i.e. to understand design in the light of function, or contribution to fitness. For this we combine constraint-optimization modeling techniques, theory and quantitative experimentation (laboratory evolution, population and single-cell based cultivation and readouts). The main organisms are currently Lactoccocus lactis, Escherichia coli and Saccharomyces cerevisiae.

Portrait of Johan  Thevelein

After PhD studies at KU Leuven (Belgium), he spent a post-doctoral period at Yale University (USA), and became appointed as professor at the KU Leuven and later also as Director of the Department of Molecular Microbiology of the life sciences research institute VIB (Belgium). His research focuses on the mechanisms involved in nutrient sensing and signaling in yeast and the polygenic analysis of complex traits for the development of superior industrial yeast strains.

Portrait of Karin  Thevissen

Her main research activities are related to drug discovery, especially in the anti-infective field (including antifungal and antibiofilm compounds) as well as in the field of anti-apoptosis, the latter related to disorders such as Wilson's disease and metabolic syndrome. For this diverse set of drug discovery tasks, her lab uses yeast as a model organism. Antifungal/antibiofilm and anti-apoptotic compounds are subsequently further evaluated in appropriate human cell lines, in lower model organisms (e.g. worm or zebrafish) and in higher eukaryotic organisms (rodent). A major part of her research focuses on unraveling the mode of action of the antifungal/antibiofilm and anti-apoptotic compounds using yeast as a model organism.

Portrait of Vladimir  Titorenko

Vladimir Titorenko is a professor at Concordia University (Montreal, Canada). His group investigates molecular mechanisms underlying cellular aging, survival and death in the yeast Saccharomyces cerevisiae. He also uses yeast as a model organism for identifying novel longevity-extending and anti-tumor natural compounds as well as for elucidating the evolution of longevity regulation mechanisms within ecosystems.

Portrait of Michel  Toledano

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Portrait of Mick  Tuite

His major research goals are to understand the mechanism of propagation and the phenotypic impact of prions in fungi, especially in Saccharomyces cerevisiae. The approaches his lab takes are primarily in vivo, exploiting a wide range of genetic and cell biology tools to probe the behaviour of this unique class of epigenetic elements both in laboratory and ‘wild’ strains of yeast. A particular focus is on the cellular factors (e.g. molecular chaperones) that contribute to both the de novo generation and continued propagation of the [PSI+] prion.

Portrait of Nilgun E.  Tumer

Dr. Nilgun E. Tumer has pioneered the use of Saccharomyces cerevisiae as a model to study the mechanism of action of ribosome inactivating proteins (RIPs) such as ricin, pokeweed antiviral protein, Shiga toxins and trichothecene mycotoxins produced by Fusarium graminearum, which causes Fusarium head blight (FHB). RIPs depurinate the α-sarcin/ricin loop (SRL) of the large rRNA and inhibit protein synthesis. Fusarium mycotoxins such as dioxynivalenol (DON) accumulate in wheat and barley and are major problems for food safety. Dr. Tumer investigates how RIPs interact with ribosomes, inhibit translation and cause cell death and how trichothecene mycotoxins affect mitochondria.

Portrait of Jessica Tyler

The Tyler lab focuses on analyses of the influence of chromatin assembly and disassembly on genomic processes and aging, predominantly in budding yeast.

Portrait of Peter Uetz

Peter Uetz earned his PhD at the European Molecular Biology Laboratory studying the biochemistry of vertebrate limb development. As a postdoc at the University of Washington in Seattle (USA) he published the first comprehensive protein interaction map of yeast. Subsequently, he studied protein interaction networks in bacteria and phage. Uetz is currently an Associate Professor at the Center for the Study of Biological Complexity at Virginia Commonwealth University (USA) where he continues to study protein-protein interactions, protein function and host-pathogen interactions. http://www.vcu.edu/csbc/uetz/uetz2.html

Portrait of Néstor  Uzcátegui

He earned his Ph.D. at the University of Tübingen (Germany) and did a post-doctoral stay at the Wayne State University (USA). He is currently a full professor at the Institute for Anatomy of the Central University of Venezuela (Venezuela). He is interested in: A) the biology of the Trypanosoma and Leishmania, particularly autophagy and cell death; B) membrane transport proteins in protozoa parasites, especially proteins belonging to the aquaporin family; C) their association with physiological processes, and their pharmacological importance.

Portrait of Marina  Vai

Marina Vai is a full professor of Molecular Biology at the University of Milano-Bicocca (Italy). She has long been interested in the biogenesis of the fungal cell wall with particular emphasis on a family of [beta]1,3-glucanosyltransferases of Saccharomyces cerevisiae. Her current laboratory projects are mainly centered on yeast chronological aging and the underlying metabolic pathways.

Portrait of Sergei Vakulenko

His laboratory is interested in the mechanisms and evolution of antibiotic resistance in bacteria.

Portrait of Ida  van der Klei

Ida van der Klei is a professor in Molecular Cell Biology at the University of Groningen (The Netherlands). Her group studies various aspects of peroxisome biology in yeast (Saccharomyces cerevisiae, Hansenula polymorpha), including peroxisome function, biogenesis and dynamics. In addition, she studies peroxisomal quality control processes such as peroxisomal proteases and pexophagy as well as the role of peroxisomes in ageing.

Portrait of Assaf  Vardi

Assaf Vardi is a senior scientist in the department of Plant Sciences at the Weizmann Institute of Science (Israel). Vardi has a long-standing expertise in cell signaling and stress physiology in several key marine protist model systems and in natural communities in response to diverse environmental stress conditions. His main interest is to investigate the signal transduction pathways related to programmed cell death (PCD), cell-cell communication, host-virus interactions, autophagy and chemical-based defense in marine photosynthetic microorganisms. As a marine microbiologist he studies the role of infochemicals in regulating cell fate, life cycle and in mediating microbial trophic-level interactions in the marine environment.

Portrait of Arnaldo  Videira

He prepared a PhD thesis at the University of Munich (Germany) that was presented to the University of Porto (Portugal), where he is currently a professor of Molecular Genetics at ICBAS-Instituto de Ciências Biomédicas Abel Salazar. He has long been interested in mitochondrial biogenesis and bioenergetics and its relevance for disease. His current research interests focus on the molecular characterization of novel proteins and metabolic pathways involved in programmed cell death, including the mitochondrial connection.

Portrait of Raymund J. Wellinger

Research in the Wellinger lab is focused on mechanisms governing chromosome stability using Saccharomyces cerevisiae as model organism. In particular, his group is interested in telomeres, their chromosome capping function and how they set themselves apart from other fortuitous chromosome ends. In addition, his lab investigates structure function relationships in the telomerase holo-enzyme, using the telomerase RNA as a starting point.

Portrait of Joris Winderickx

Joris Winderickx is a professor at the Department of Biology of KU Leuven (Belgium). He has ample expertise on nutrient- and stress-dependent signaling in yeast. Being convinced that several signaling cascades in yeast are at the origin of more complex pathways in metazoans, he pioneered on the use of yeast as a model to study the molecular mechanisms underlying a variety of human disorders, where the primary focus is on degenerative protein (mis)folding diseases.

Portrait of Dennis Winge

The Winge laboratory is focused on assembly of mitochondrial respiratory complexes with an emphasis on formation of cofactor centers. His group is interested in mitochondrial acquisition and use of metals (copper, zinc and iron).

Portrait of Stephan  Witt

His lab uses yeast to study the mechanism of toxicity of the human Parkinson's disease-associated protein alpha-synuclein. His group’s efforts are geared to identifying genes and drugs that suppress alpha-synuclein toxicity, uncovering the molecular pathways affected by alpha-synuclein and validating findings in mammalian models. His general areas of interest are molecular chaperones, lipid metabolism, misfolded proteins and human disease, especially neurodegeneration.

Portrait of Stefan  Wölfl

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Portrait of Chul-Su  Yang

Dr. Yang has focused on investigating molecular mechanisms in innate immune signaling, i.e., Toll-like receptors- and Dectin-1-dependent pathways, phagocytes as well as molecular and cellular pathogenesis of intracellular microbes infection, especially on Mycobacteria, Listeria, Candida, Toxoplasma, and Influenza infection.

Portrait of Vanina Zaremberg

Her research program concentrates on the study of lipid metabolism and its interconnection with lipid signalling in eukaryotes, using budding yeast as model organism. Her group currently focuses on regulation of phosphatidic acid metabolism, mode of action of antitumor lipid drugs and tocopherols. Her lab’s research includes a wide combination of approaches from the fields of biochemistry, yeast genetics, cell and molecular biology.

Portrait of Yu-Zhong  Zhang

His group follows three main interests: (i) cold-adaptation of marine psychrophilic bacteria, (ii) enzymology of marine microorganisms in the extreme environments, and (iii) the structure, function and evolution of phycobilsomes in cyanobacteria and red algae.

Portrait of Zhaojie J Zhang

He studies cell cycle regulation and cell cycle alteration under external and/or internal stress, using budding yeast as a model system. His laboratory is particularly interested in the mechanism of stress-induced cell death at both the cellular and molecular levels.

Portrait of Richard  Zhao

Richard Zhao is a professor of pathology, microbiology-immunology and human virology at the University of Maryland, School of Medicine (USA). His laboratory developed a fission yeast model to study HIV-1, especially the role of HIV-1 viral protein R (Vpr) in cell cycle G2/M regulation, cell death/apoptosis and viral pathogenesis. A current research interest is the development of high throughput fission yeast platforms for screening of anti-HIV drugs, including HIV-1 Vpr and drug-resistant proteases.

Portrait of Xilin Zhao

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Portrait of Bing  Zhou

He is interested in mitochondrial biology, metal (zinc, iron and copper) biology and their relevance to death, the action of drugs and neurodegenerative diseases. His group studies these questions using the yeast and fruit fly model organisms.

Portrait of Cong-Zhao Zhou

His current research is focused on the structural basis of interaction between human host cells and pathogens. His group is seeking the universal molecular mechanisms of bacterial infection and host response.