FIGURE 2: Ras1 signals via Cdc42 and Rac proteins to regulate many processes within the C. neoformans cell. Upon activation Ras1 associates with Cdc24 and subsequently activates the Rho-type GTPases Rac1/Rac2 and Cdc42/Cdc420. These proteins are involved in multiple cellular processes such as cell cycle progression, mating and morphogenesis.