FIGURE 1: Summary of our findings.

During replicative aging of budding yeast, there is a loss of half of the nucleosomes over the genome, leading to increased transcription from all genes in the genome, increased amounts of DNA breaks, translocations, amplifications, retrotransposition and transfer of mtDNA to the nucleus. Replic. mach., replication machinery; Repair mach., repair machinery; Transcr. mach., transcription machinery.