FIGURE 1:

(A) A schematic depicting a typical yeast gene whose transcription profile is made up of multiple clusters (numbered from 5’ to 3’). Major mRNA isoforms within clusters are indicated by small gray triangles. A stability element (green rectangle) is present in major isoform 4 but absent in isoform 3 and shorter mRNA species.

(B) Major isoform 4 possesses a longer half-life than isoform 3 due to the presence of a stability element. In this model, isoform 3 has no stability element and is readily degraded by the exosome complex (yellow Pac-Man shape) from the 3’ to 5’ direction. The presence of either a polyU-poly(A) tail structure or a stem-loop near the 3’ terminus of isoform 4 blocks exosome-dependent degradation.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.

Close