FIGURE 1: Diagram of the Mediator complex depicting the targets of Cdk8 module regulation.

Cartoon of the RNA polymerase II holoenzyme bound to DNA. The core mediator complex with the tail, middle and head regions are indicated. The Cdk8 module composed of cyclin C, Cdk8, Med12 and Med13 is indicated. Reported regulatory targets of cyclin C-Cdk8p are indicated by arrows.