FIGURE 5: The heme-mediated inhibitory action of ARTs is not through interference of the iron-sulfur cluster biogenesis.

(A) Compared with WT, the iron-sulfur cluster mutants do not exhibit extra sensitive phenotypes to both ART and DHA. All strains are in the BY4742 background.

(B) DHA does not affect the respiration ability of either WT or HEM2-KD strains on fermentable media.

(C) DHA does not affect the cytochrome c oxidase activity of either WT or HEM2-KD yeast strains. ns, no significance.