FIGURE 5: The ubiquitin/proteasome-associated mutants identified in the lithium screen have defects in proteins implicated in several stages of the ubiquitin/proteasome system. The strains defective in proteins belonging to a specific functional category of the ubiquitin/proteasome system (for example E1, or DUB) are color-coded and indicated based on their strain designation at the Fungal Genetics Stock Center (http://www.fgsc.net/, see Table 1). Strains in bold are those that were found to be defective in capsule formation (see Figure 6). Ub, ubiquitin; Nedd8, neural precursor cell expressed, developmentally down-regulated 8; SUMO, small ubiquitin-related modifier; URM1, ubiquitin-related modifier 1; E1, ubiquitin-activating enzyme; E2, ubiquitin-conjugating enzyme; E3, ubiquitin ligase; DUB, deubiquitinating enzyme.