Back to article: Too much of a good thing: Overproduction of virulence factors impairs cryptococcal pathogenicity
FIGURE 1: The transcription factor Pdr802 is a negative regulator of cryptococcal capsule thickness and Titan cell formation. Upper panel, India ink staining of fungal cells isolated from the lungs of mice infected with the wild-type (KN99α), deleted (pdr802), and complemented (PDR802) strains at 3 days post-infection. Lower panel, India ink staining of the same strains after growth in Titan cell induction media in vitro for 72 hours at 37°C and 5% CO2. All images are to the same scale; scale bar, 10 µm.