FIGURE 4: Representation of the variants found in resistance genes typically subjected to mutations conferring resistance to azoles or echinocandins. Protein domains are represented to provide visual illustration of the variants position in the protein context. (A) Upper mutations – PDR1 variants identified in the genomes of azole resistant isolates but not in the genomes of susceptible isolates; Bottom mutations – PDR1 variants identified in the genomes of multi resistant isolates but not in the genomes of susceptible isolates. (B) Upper mutations – FKS1 variants identified in the genomes of echinocandin resistant isolates but not in the genomes of susceptible isolates; Bottom mutations – FKS1 variants identified in the genomes of multi resistant isolates but not in the genomes of susceptible isolates. (C) FKS2 variants identified in the genomes of echinocandin resistant isolates but not in the genomes of susceptible isolates. DBD – DNA Binding Domain, ID – Inhibitory Domain, MHRD – Middle Homology Regulatory Domain, AD – Activation Domain, HS1 – Hotspot 1, HS2 – Hotspot 2.