Selected examples of an inoculum effect in antibiotic testing.

Low concentrations of quorum protection molecules could provide an alternate explanation.

8. Galgiani JN and Stevens DA (1978). Turbidimetric studies of growth inhibition of yeasts with three drugs: inquiry into inoculum-dependent susceptibility testing, time of onset of drug effect, and implica-tions for current and newer methods. Antimicrob Agents Chemother 13(2): 249–254. http://dx.doi.org/10.1128/aac.13.2.249

9. Castelli LA, Nguyen NP, and Macreadie IG (2001). Sulfa drug screening in yeast: fifteen sulfa drugs compete with p-aminobenzoate in Saccharomyces cerevisiae. FEMS Microbiol Lett 199(2): 181–184. http://dx.doi.org/10.1111/j.1574-6968.2001.tb10671.x

10. Steels H, James SA, Roberts IN, and Stratford M (2000). Sorbic acid resistance: the inoculum effect. Yeast 16: 1173-1183. http://www.ncbi.nlm.nih.gov/pubmed/?term=10992281

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