mCherry-expressing Hoechst-stained Plasmodium berghei parasites (pink cytoplasm, blue nuclei) revealing swollen lysosome-like organelle (central organelle in yellow) upon exposure to a high concentration of the antimalarial chloroquine. Image acquired by Kevin SW Tan (National University of Singapore, Singapore) and Jun Hong Ch’ng (Karolinska Institutet, Sweden); modified by MIC. The cover is published under the Creative Commons Attribution (CC BY) license.