FIGURE 1: MRS-dependent interchromosomal clustering during epigenetic transcriptional memory.

Portions of homologous chromosomes (yellow, green) are depicted clustering via their respective DNA zip code elements, associating with intermediary proteins and nuclear pore complexes (NPC). GRSI-mediated clustering is retained throughout the cell cycle independently of nuclear membrane binding. Memory-based clustering is specific to given genes/zip codes, possibly by virtue of distinct NPC adapter proteins. Memory-based clustering is dependent on prior clustering via GRSI elements during the activation phase.