FIGURE 2: Dose-dependent effects of 8 drugs on Aβ₄₂-RF activity as measured by cell growth.

Aβ₄₂-RF expressing cells were treated with each drug at the indicated concentrations. Their effects on cell growth were measured as OD₆₀₀ in +Ade and -Ade media after 4 and 5 days respectively (see Materials and Methods for details). Growth in -Ade is dependent upon Aβ₄₂-RF release factor activity. This activity is expected to be reduced by oligomerizartion. Growth on +Ade does not require Aβ₄₂-RF release factor activity and is used as a control in the presence of each drug. Shown is the relative growth in the presence vs. absence of each drug. Error bars show the standard deviation from three replicates. The asterisks show significance levels of **P < 0.01 or *P < 0.05 according to the Student’s t test between DMSO (0) control and drug treatment at marked concentration for growth in -Ade.