FIGURE 4: Analysis of connectors based on their real expression behavior. The CoRegScore evaluates to what extent connectors are regulated in the predicted direction. A positive score implies that the majority of algorithm-determined connectors are regulated in the same direction as the top100-hits. To obtain a CoRegScore of 100, the predicted connectors have to be the next genes after the top100 in terms of expression differences. The CoRegScore is calculated as described in the materials and methods section. Depicted here is the variability of the CoRegScore depending on the number of connectors derived from the pairwise co-regulation matrix. 100 random experimental sets were constructed and evaluated under the same conditions to obtain the average score of a random data set and the standard deviation of this value.