FIGURE 1.

(Left) Representative dendrogram of the MAPEG superfamily including the malaria parasite membrane GSTs Plasmodium yoelii HEP17 (PyHEP17) and Plasmodium falciparum EXP1 (PfEXP1), Escherichia coli MGST (EcMGST), Anopheles gambiae MGST (AgMGST), rat MGST1, and human MGST3, 5-lipoxygenase activating protein (FLAP), MGST2, and leukotriene C4 synthase.

(Right) Proposed model of PfEXP1 in Plasmodium falciparum infected erythrocytes. The membrane protein PfEXP1 catalyzes the conjugation of reduced glutathione (GSH) onto hematin and onto the drug artemisinin (ART) and thus contributes to their detoxification.