FIGURE 1A: Orthologies of membrane transport proteins of the malaria parasite.

Extensive amino acid based reciprocal homology searches were performed to establish orthologues of the all Plasmodium channels/pores (TCDB Class 1.A/B [19]; pink), pumps (3.A; purple), porters (2.A; cyan), and unclassified, putative MTPs (yellow) in representative species of the entire breadth of the eukaryotic domain. Dot sizes indicate the fraction of the sequence length over which homology was detected; red dots indicate reciprocal orthologues. When a protein has not been given a name, these are indicated by their P. falciparum geneID number. MTPs for which the encoding genes were deleted successfully are indicated in blue, unsuccessful gene deletions suggesting essential functions during blood-stage development are highlighted in red. (®, species harbouring plastids of red algal origin; *, putative heavy metal transporting MTPs). Please see the continuation of the table in Figure 1B.

19. Saier MH, Reddy VS, Tamang DG, and Västermark A (2014). The transporter classification database. Nucleic Acids Res 42(Database issue): D251–D258. http://dx.doi.org/10.1093/nar/gkt1097