FIGURE 2: The RVxF motif in UIS2 phosphatase domain.

P. berghei UIS2 (1321 amino acids) contains a phosphatase domain (roughly residues 535-1054). The amino acids around RVxF motif in UIS proteins from P. berghei, P. yoelii, P. chabaudi, P. vivax, P. knowlesi, and P. falciparum are aligned. The cyan area shows the conserved phosphatase domain and the gray region shows the insertion in UIS2 relative to 1UTE (the best matching phosphatase in Protein Data Bank).