The non-invasive highly pro-inflammatory mxiD Shigella GFP strain (green) promotes pronounced HP1g phosphorylation in the colon. The picture shows a phospho-HP1g immunostaining (visualized in red) co-localizing with Dapi (blue) and principally located at the lamina propria and the epithelial layer.Image acquired by Benoit Meijer (Institut Pasteur, France); modified by MIC. The cover is published under the Creative Commons Attribution (CC BY) license.