FIGURE 7: TL-532 induces apoptotic cell death in cancer cells but not in normal primary cell counterparts. Cell viability – expressed in percentage of untreated cells – was determined by MTS assay (A, C), and apoptosis – expressed in fold increase compared to the mock control – was determined using AnnexinV-Glo assays (B, D), after a 24 hr of dose escalation treatments of TL-532. (A-B) TL-532 induces apoptosis and reduces viability specifically in NCI-H292 wt lung cancer cells but not in the normal Human Bronchial Epithelial Primary Cells (HBEpCs). (C-D) TL-532 induces apoptosis and reduces viability specifically in U937 wt histiocytic lymphoma cancer cells but not in normal Primary Human Monocytes (PMo). All data are the means of three independent assays. Results are expressed as mean ± 95% confidence interval.