FIGURE 4: Model depicting the role of caspase 3 in proteostasis and mitochondrial function. In normal physiological state, moderate activation of caspase 3 leads to the disaggregation of TDP43 protein inhibiting its association with PHB2 leading to normal mitochondrial function. On the contrary, caspase 3 inhibition will facilitate the association of TDP43 with PHB2 which will lead to impaired mitochondrial function and can act as a driver for pathologies such as ALS.