Back to article: The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg

FIGURE 4: Function of non-Inc C. trachomatis effectors. (A) C. trachomatis effectors (TarP, TmeA, TmeB, CT166, CT622) packed in EBs and delivered into host cells during invasion; besides TarP, TmeA and CT622 also promote C. trachomatis invasion but their mode of action is unknown. (B) C. trachomatis non-Inc proteins that have been detected in the host cell cytoplasm, nucleus, or inclusion membrane (Cdu1, Cdu2, CteG, Lda1, Lda2, Lda3, NUE, pGP3, CT311, CT620, CT621, CT711, and CT795; GlgX, CopN, Cap1, GlgA, HtrA, and CPAF are not represented) or for which there is functional evidence for an effector role (CT619, CT712, CT847). It is unclear whether these proteins are delivered into host cells by EBs or by RBs (as represented), or by both chlamydial forms. Among the chlamydial proteins represented and not binding a host cell protein, pGP3 has been shown to interact with the antimicrobial peptide cathelicidin LL-37 but this likely occurs extracellularly [276]. See list of abbreviations, main text, and Table 2 for details.

276. Hou S, Sun X, Dong X, Lin H, Tang L, Xue M, Zhong G (2019). Chlamydial plasmid-encoded virulence factor Pgp3 interacts with human cathelicidin peptide LL-37 to modulate immune response. Microbes Infect 21(1): 50-55. doi: 10.1016/j.micinf.2018.06.003

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