Back to article: More than flipping the lid: Cdc50 contributes to echinocandin resistance by regulating calcium homeostasis in Cryptococcus neoformans

FIGURE 1: Mechanisms of echinocandins resistance.(A) Mutations in FKS1, encoding the catalytic subunit of β-1, 3-glucan synthase, change its expression and the sensitivity of glucan synthase to echinocandins. (B) Echinocandins cause cell wall stress by inhibiting β-1,3-glucan synthase. The calcineurin, protein kinase C (PKC), and high osmolarity glycerol response (HOG) pathways allow cells to adapt to cell wall stress via compensatory cell wall biosynthesis and remodeling.

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