Back to article: Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes

TABLE 1: DNA repair genes assayed in Saccharomyces cerevisiae.

Several yeast-based assays have been developed to characterize human genes involved in Mismatch Repair (MMR), Homologous Recombination (HR), Post Replication Repair (PRR), Base and Nucleotide Excision Repair (BER, NER), and Non-Homologous End Joining (NHEJ). The name of the yeast and human gene is shown; BRCA1 and BRCA2 have no yeast homologue. TA, transcription activation assay; SCP, Small Colony Phenotype; YLP, Yeast Localization Phenotype; GR, gene reversion; MMS, methyl methane-sulfonate, HU hydroxyurea.

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