FIGURE 2: GlcN6P sensing and signaling by RapZ.(A) Regulatory cascade initiated by RapZ when sensing GlcN6P scarcity. (B) Cartoon representation of the X-ray crystal structure of tetrameric RapZ (upper panel). The middle panel shows localization of the RNA binding domain and a putative ligand binding pocket occupied by malonate within the RapZ-CTD swapped dimer. Bottom panel: Close-up view of the residues forming the presumptive GlcN6P binding site with bound sulfate. The cartoons illustrating the RapZ structure are from Gonzalez et al., 2017, Nucleic Acids Res. 45(18):10845-10860.