FIGURE 1: Targets of LasR-regulated proteases. LasR-regulated proteases can cleave a large number of host targets ranging from components of the extracellular matrix and tight junction to immune mediators, adhesion molecules and other molecules. Some targets, such as ICAM-1, can be degraded by multiple LasR-regulated proteases, while others such as ENaC are proteolytically activated rather than inactivated.