Back to article: DNA polymerase III protein, HolC, helps resolve replication/transcription conflicts

image description

FIGURE 1: Events leading to fork breakage after collision of DNA pol III with transcription elongation complexes (TEC). Diagrammed are events ensuing from codirectional collisions, but can occur similarly with head-on collisions. RNAP is illustrated in red, the fork helicase in green. (A) The fork encounters a TEC, that blocks DNA polymerization. (B) The fork moves on, replication is restarted. (C) A single-strand gap is left behind. (D) Convergence of a second fork (helicase marked with lt green) onto the gap. (E) The resulting one-ended double-strand break.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.