FIGURE 1: Schematic of T6SS cluster Aux3 domestication in the transition from the environmental to the pandemic population of V. cholerae. (Left) Theoretical phylogenetic tree of the V. cholerae population and other closely related Vibrios. Green cells = Aux3(+) isolates. Blue cells = Aux3(-) V. cholerae. Purple cells = close relative, Aux3(-) Vibrios. Green dashed arrows = theoretical Aux3 lateral transfer events. (Right) Schematic of environmental (bottom) and pandemic (top) Aux3 clusters. The weight of the arrows between the linear and circular Aux3 modules represent the excision quantity. Grey boxes represent homologous regions between pandemic Aux3 and environmental Aux3. Black dot represents the common ancestor of the pandemic clade and its closely-related environmental sister clade. Grey dot represents the common ancestor of the pandemic clade.