FIGURE 4: ExDNA sequences correspond to subsets of eccDNA depending on active metabolism. Venn diagrams comparing genes found in eccDNA with those occurring in exDNA from different growth media. Genes completely or partially represented in at least one S. cerevisiae eccDNA sample (N=1957) [33], are compared to those occurring in exDNA purified from exhausted media of LFC and either EFC (A) or EFC 6h (B). ExDNA from respiratory LFC and, to a lesser extent EFC 6h, shows higher similarity with eccDNA as compared to the fermentative EFC.

33. Møller HD, Parsons L, Jørgensen TS, Botstein D, and Regenberg B (2015). Extrachromosomal circular DNA is common in yeast. Proc Natl Acad Sci 112(24): E3114–E3122. 10.1073/pnas.1508825112