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Extracellular DNA secreted in yeast cultures is metabolism-specific and inhibits cell proliferation
Table 2. Number and percentage of genes in sequenced exDNA from exhausted media of different fedbatch conditions (EFC and LFC at the end of the runs and EFC at 6h) compared to eccDNA [33]. The percentages refer to genes included in specific KEGG metabolic pathways either exclusively associated to respiratory metabolism (TCA cycle, pentose phosphate, oxidative phosphorylation) or common to both fermentative and respiratory metabolism (glucose pathways and cell cycle).
33. Møller HD, Parsons L, Jørgensen TS, Botstein D, and Regenberg B (2015). Extrachromosomal circular DNA is common in yeast. Proc Natl Acad Sci 112(24): E3114–E3122. 10.1073/pnas.1508825112