FIGURE 1: Schematic representation of NPC, Centro-mere/Kinetochore clustering and proteasome localization to the NE. Working model. The fission yeast nuclear basket component Alm1 is required for proper localization of the proteasome and its anchor Cut8 to the NE. Deregulation/delocalization of proteasome from the NE results in unbalanced kinetochore composition, which leads to chromosome missegregation.