Back to article: Cross-species complementation of bacterial- and eukaryotic-type cardiolipin synthases

FIGURE 1: Types of cardiolipin (CL) synthases and their reaction mechanisms. (A) CLS belonging to the structural family of CDP-alcohol phosphatidyltransferases (CAP) catalyze an irreversible reaction between phosphatidyl glycerol (PG) and cytidine diphosphate diacylglycerol (CDP-DAG) to form CL and CMP, whereas CLS of the phospholipase D (PLD) type catalyzes a reversible transphosphatidylation reaction, using one molecule of PG together with another phosphatidyl donor (PG, PE, see main text) to form CL. (B) Schematic representation of the domain arrangement of CLS from yeast (S. cerevisiae Crd1; CAP-type) and T. brucei (TbCLS; PLD-type). The predicted transmembrane domains and conserved functional domains are indicated.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Please refer to our "privacy statement" and our "terms of use" for further information.