Back to article: Endolysosomal pathway activity protects cells from neurotoxic TDP-43

FIGURE 1: Lysosomal degradation of TDP‑43. The lysosome (or the yeast vacuole) contains a number of proteases, which enable the degradation of proteins. Protein substrates are transported to the lysosome either via the endolysosomal (or endosomal-vacuolar) pathway (left) or via (macro-)autophagy (right). Both pathways contribute to the degradation of TDP‑43. Furthermore, TDP‑43 is a potent inhibitor of the endolysosomal pathway, which is required for lysosomal function. For details see main text.

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