Back to article: Placeholder factors in ribosome biogenesis: please, pave my way

Figure 2: Rlp24 functions as a placeholder factor for the L24 r-protein. (A) Position of Rlp24 (red) in the early pre-60S r-particles purified with Nog2-TAP (PDB ID: 3JCT; [40]). (B) Position of L24 r-protein (red) in the mature 60S r-subunit (PDB ID: 3U5I, 3U5H; [44]). Particles are viewed from the subunit interface. For orientation, the positions of the 5S rRNA (yellow) and the L23 r-protein (royal blue) have been highlighted. The ITS2 foot has also labelled in A. Note that the last ca. 50 amino acids from the C-terminal part of Rlp24 and ca. 20 amino acids from the C-terminal end of L24 could not be modelled in the respective structures. The rest of rRNAs are coloured in pale blue and the rest of r-proteins and/or factors in light cornflower blue.

40. Wu S, Tutuncuoglu B, Yan K, Brown H, Zhang Y, Tan D, Gamalinda M, Yuan Y, Li Z, Jakovljevic J, Ma C, Lei J, Dong MQ, Woolford JL, Jr., Gao N (2016). Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Nature 534(7605): 133-137.

44. Ben-Shem A, Garreau de Loubresse N, Melnikov S, Jenner L, Yusupova G, Yusupov M (2011). The structure of the eukaryotic ribosome at 3.0 Å resolution. Science 334(6062): 1524-1529.

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