Back to article: Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK

FIGURE 6: RNA-seq analysis of gene expression in WT, snf1∆, and by-pass suppressor strains. (A) Genes (986) that were upregulated at 24 hr in the WT strain (JS1256), but not in the snf1∆ strain (JS1394) were analyzed by Pearson correlation clustering and displayed as a heat map of Z-score from the mean of all three strains. Cluster 1 (vertical black bar) represents 359 genes in which expression was restored in JS1416 compared to JS1394. (B) Gene ontology (GO) terms and p-values associated with cluster 1 using Holm-Bonferroni correction. (C) Top 15 enriched transcription factors on the promoters of genes with >2-fold enrichment in JS1416 compared to JS1394 (from Supplemental Table S1).

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