Back to article: Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica

TABLE 2. Metabolomics captures known metabolic changes of a purH mutant.

Untargeted metabolomics was performed on WT and ΔpurH mutant of S. enterica grown in glucose minimal medium supplemented with adenine and thiamine. Relative concentrations of 3 key metabolites whose physiological changes have been previously described were extracted.

a Experimental replicates consisted of 3 biological replicates of each strain.

b Fold changes were the ratio of the average MS ion intensities (peak areas) in WT and ΔpurH strains (ΔpurH/WT).

c p-values indicative of statistically significant differences are noted as follows <0.05 (**), <0.01 (***).

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