Research – Page 2 – Microbial Cell

Research, Research Articles

Scp160 deletion suppresses TDP-43 aggregation and toxicity in <i>Saccharomyces cerevisiae</i>

Scp160 deletion suppresses TDP-43 aggregation and toxicity in Saccharomyces cerevisiae

Joan Castells-Ballestera and Natalia Shcherbik

Deletion of SCP160 or BFR1 reduces TDP-43 toxicity without lowering TDP-43 protein abundance and suppresses prominent TDP-43, Htt103Q, and VHL aggregation, while SCP160 deletion also shifts residual TDP-43 foci toward the ER.

The p53 DNA-Binding (Core) Domain can form a prion that seeds prion formation in full-length p53

Mathilde Kadouch¹, Christelle Marchal¹, Sei-Kyoung Park², Sangeun Park², Sabine Castano¹, Susan W. Liebman² and Christophe Cullin¹

In yeast the p53 core-domain forms a self-propagating prion that inactivates a reporter and converts untagged full-length p53 to a prion. R175H in the tagged chimera shows 18x higher prionization, linking it to p53 inactivation in human cancers.

Sorbic acid triggers rapid formation of proteasome storage granules in <i>Saccharomyces cerevisiae</i>

Sorbic acid triggers rapid formation of proteasome storage granules in Saccharomyces cerevisiae

Shoei Tanaka¹, Mitsuki Imajo¹, Mieko Hayashi², Akira Matsuura² and Shingo Izawa¹

This study demonstrates that sorbic acid, a common food preservative, induces the fastest reported proteasome storage granule (PSG) formation in yeast within 30 min, highlighting differences from other PSG-inducing conditions like acetic acid stress.

A time-resolved high-throughput screening of fission yeast deletion mutants for oxidative stress resistance

Mohammadtaha Pirsalehi, Rowshan Ara Islam, Kristal Ng, Olga Xintarakou, Peter Harold Thorpe and Charalampos Rallis

By capturing dynamic trajectories rather than static outcomes, this study exposes hidden layers of growth under oxidative stress and identifies new genetic determinants of cellular resilience in fission yeast.

Clonal spread and environmental persistence of carbapenem-resistant high-risk <i>Pseudomonas aeruginosa</i> in critical-care units of a Chilean national referral center for burn and trauma patients (2022)

Clonal spread and environmental persistence of carbapenem-resistant high-risk Pseudomonas aeruginosa in critical-care units of a Chilean national referral center for burn and trauma patients (2022)

Camila Ibarra¹, Gustavo Araya², Alhejandra Alvarez², Leonardo Enríquez², Carolina Arellano², Fabricio Alarcón¹, Constanza Fernández¹, Claudio Vargas¹, Rodrigo Vera¹ and Roberto M. Vidal²

This study highlight the circulation of high-risk P. aeruginosa clones in Chile and underscore the importance of molecular epidemiology in guiding infection control, optimizing antimicrobial therapy, and mitigating the clinical and economic burden of CRPA.

The transcriptome of dendritic cells redraws the boundaries between pathogenicity and commensalism in yeast

Lisa Rizzetto¹, Irene Stefanini², Stefano Nenciarini³, Monica Di Paola³, Samantha Riccadonna¹, Ivo G. Gut^4,5, Marta Gut^4,5, Simon Heath^4,5 and Duccio Cavalieri³

Our immune system meets many fungi, but reacts strongly to only a few. The comparison of key fungal species showed that responses differ mainly in timing and not just genes, highlighting the need to rethink what makes fungi harmful vs. harmless.

Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in <i>Saccharomyces cerevisiae</i>

Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in Saccharomyces cerevisiae

Çağla Ece Olgun^1,a, Gizem Turan Duman^1,a, Gizem Güpür¹, Hamit İzgi¹, Mariam Huda², Demet Çetin³, Zekiye Suludere⁴, Fatma Küçük Baloğlu⁵, Ayşe Koca Çaydaşı² and Mesut Muyan¹

This study demonstrates that the conserved yeast protein Moh1 links metabolism, gene expression, and cell structure, thereby altering cell envelope permeability and leading to selective stress responses.

Fungistatic effect of sorbic acid on yeast cells via translational repression involving eIF2α phosphorylation and formation of Ded1- and eIF2B-granules

Haruka Yoshiyama¹, Wataru Nomura² and Shingo Izawa¹

The findings of this study provide new insights into the physiological effects of sorbic acid on yeast cells, specifically regarding the regulation of translation-related factors.

Occlusal types shape oral microbiome stomatotypes and metabolic landscapes: A multi-omics perspective on host-microbe interaction

Yufeng Duan^1,a, Zheng Liu^2,3,a, Wenting Lu^1,a, Ning Zhao¹, Lingjun Yuan¹, Zhenxia Li¹, Ting Zhou¹, Shengzhao Xiao¹, Dian Jing¹, Xiaowen Zheng¹, Wentao Shi⁴, Chao Liu^1,*, Haixia Lu^5,*, Qiang Feng^6,* and Bing Fang^1,*

This study reveals how occlusal types shape oral microbiome “stomatotypes” and metabolic profiles in adolescents. It offers fresh insights that host anatomy drives microecology which may be associated with personalized oral health.

Sugar-induced cell death (SICD) in Saccharomyces cerevisiae: insights into nitrogen-mediated rescue and apoptotic cell death pathways

May 11, 2026

This study examined mechanisms through which yeast sugar-induced cell death can be prevented. High concentrations of glucose induced a catastrophic response that was only rescued by highly preferred nitrogen sources and by preventing nuclear localization of specific cell death proteins.

TOR-dependent regulation of the yeast homolog of the juvenile Batten Disease-associated gene CLN3

March 11, 2026

This study identifies conditions and genes that induce BTN1 expression in yeast. We show that BTN1 expression is regulated by translational control and by the mTOR1 pathway. An understanding of when and why BTN1 expression will aid in understanding the expression of CLN3, which may be helpful in the treatment of this devastating disease.

Metagenomic and microbiological analyses of historical manuscripts for bacterial community profiling and bacteria-related biodeterioration assessment

March 1, 2026

By documenting both culturable and non-culturable taxa, this work provides a foundational dataset for understanding bacterial contributions to manuscript stability and offers a methodological framework for future research on biodeterioration dynamics in Islamic and global documentary heritage.

Overcoming phagocytosis resistance of hypervirulent Klebsiella pneumoniae by directly targeting capsules

February 16, 2026

This study highlights a promising strategy for disarming hypervirulent K. pneumoniae by directly targeting its key virulence factors and provides novel insights into antibacterial therapeutic approaches against this clinically significant pathogen.

VapA/Scs2 sustains polarized growth in Aspergillus nidulans by maintaining AP-2-mediated apical endocytosis

February 5, 2026

To explore the functional significance of ER–PM contact sites in filamentous fungi, we identified and genetically characterized all Aspergillus nidulans proteins homologous to Snc2/VAP, Ist2, or tricalbins.

Genetic make-up and regulation of the L-lysine biosynthesis pathway in Vibrio natriegens

February 3, 2026

This study analysed the make-up and regulation of the biosynthetic pathway for L-lysine and related L-aspartate family amino acids (AFAAs) in Vibrio natriegens DSM759 to provide a comprehensive basis for future metabolic engineering endeavours aiming at developing this strain into an amino acid overproducer.

Regulation of extracellular vesicles for protein secretion in Aspergillus nidulans

January 28, 2026

This study reveals that Aspergillus nidulans boosts extracellular vesicle production when ER-trafficked enzymes are induced, uncovering how fungi remodel their secretome through vesicle-mediated secretion to adapt to changing environments and biofilm formation.

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