TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization
April 19, 2023
In the present study, we identified a new family of TLR3 agonists that activates myeloid cells, triggers the secretion of pro-inflammatory cytokines in both myeloid and cancer cells, and induces apoptosis specifically in cancer cells.
Infinity war: Trichomonas vaginalis and interactions with host immune response
March 31, 2023
Trichomonas vaginalis is the pathological agent of human trichomoniasis with an incidence of 156 million cases worldwide. This review highlights parasite strategies to activate and stimulate or evade variated and complex immunological mechanisms related to the symptoms and clinical complications observed here.
Chlamydia pneumoniae is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells
March 11, 2019
This study found that Chlamydia pneumoniae is present more frequently in the dental plaque of individuals with periodontal disease, can invade human gingival epithelial cells causing inflammatory responses, and may therefore be a contributing factor to periodontal disease and a potential indicator of risk.
Threading Granules in Freiburg: 2nd International Symposium on “One Mitochondrion, Many Diseases – Biological and Molecular Perspectives”, a FRIAS Junior Researcher Conference, Freiburg im Breisgau, Germany, March 9th/10th, 2016
November 4, 2016
INTRODUCTION Mitochondria (greek: μίτος & χονδρίον, mitos & chondrion, i.e., thread & granule) are the power houses of eukaryotic cells, and are pivotally involved in essential metabolic processes, including iron/sulfur cluster and heme ... Read more
Bacterial genotoxin functions as immune-modulator and promotes host survival
July 28, 2016
This article comments on work published by Del Bel Belluz et al. (PLoS Pathog, 2016), which demonstrated that the typhoid toxin of Salmonella enterica serovar Typhi esembles an immune-modulatory molecule rather than a toxic agent.
Entamoeba histolytica – tumor necrosis factor: a fatal attraction
July 6, 2015
This article comments on the study "In Entamoeba histolytica, a BspA family protein is required for chemotaxis toward tumour necrosis factor" by Silvestre et al. (Microbial Cell, 2015).
Digesting the crisis: autophagy and coronaviruses
May 4, 2020
This article reviews the multifaceted role of autophagy in antiviral defense and highlights how coronaviruses, including SARS-CoV-2, interact with this pathway, raising the possibility that targeting autophagy could offer novel therapeutic strategies against COVID-19.