Publications

Uga3 influences nitrogen metabolism in Saccharomyces cerevisiae by modulating arginine biosynthesis

June 12, 2025

Nitrogen metabolism in Saccharomyces cerevisiae is tightly regulated to optimize the utilization of available nitrogen sources. Uga3 is a known transcription factor involved in the gamma-aminobutyric acid (GABA) pathway; however, its broader role in nitrogen metabolism remains unclear.

An adenine model of inborn metabolism errors alters TDP-43 aggregation and reduces its toxicity in yeast revealing insights into protein misfolding diseases

May 22, 2025

This work offers new insights into the potential interactions between me-tabolite-based amyloids and pathological protein aggregates, with broad implications for understanding protein misfolding diseases.

Advancements in vaginal microbiota, Trichomonas vaginalis, and vaginal cell interactions: Insights from co-culture assays

May 15, 2025

This review updates co-culture and co-incubation techniques for studying interactions of Lactobacillus spp., representing a pre-dominant member of the healthy vaginal microbiota; Candida spp., the most abundant yeast in the vagina, and T. vaginalis, responsible for the most widespread nonviral STI worldwide.

Influence of cervicovaginal microbiota on Chlamydia trachomatis infection dynamics

April 15, 2025

This review examines the complex interplay between the cervicovaginal microbiome, C. trachomatis infection, and host immune responses, highlighting the role of metabolites such as short-chain and long-chain fatty acids, indole, and iron in modulating pathogen survival and host defenses.

Microbiota and metabolome dynamics induced by Shiga toxin-producing E. coli in an in vitro model of an infant’s colon

April 14, 2025

This study provides new evidence of the impact of EHEC in the microbiota and metabolome dynamics in an in vitro gut model that could be useful in understanding their physiopathology in this at-risk population, considering inter-individual variabilities in gut microbiota.

Unveiling the molecular architecture of the mitochondrial respiratory chain of Acanthamoeba castellanii

March 31, 2025

This review provides a comprehensive overview of the mitochondrial res-piratory chain in A. castellanii, focusing on the key alternative components involved in oxidative phosphorylation and their roles in energy metabolism, stress response, and adaptation to various conditions.

Ampicillin treatment in persister cell studies may cause non-physiological artifacts

March 20, 2025

This study shows at the example of L2 how insufficient purification of ampicillin persister cells can lead to the generation of non-physiological artifacts and provides a novel tool to improve the removal of residual cell debris.

Clostridium scindens promotes gallstone formation by inducing intrahepatic neutrophil extracellular traps through CXCL1 produced by colonic epithelial cells

March 19, 2025

Through in vivo and in vitro experiments, we validated the reliability of C. scindens stimulating colonic epithelial cells to produce TLR2, activating the NF-κB signaling pathway, promoting CXCL1 expres-sion, and inducing intrahepatic neutrophil NETosis, which may be associated with gallstone formation.

It takes four to tango: the cooperative adventure of scientific publishing

February 21, 2025

This Editorial is the 500th article published in Microbial Cell, a journey that started in 2014 and has seen the journal grow steadily and maintain itself as a respected community platform. The foundation that has allowed for and driven this development – as for any responsible journal – is composed of four essential pillars: the readers, the authors, the editors and the referees.

Integrative Omics reveals changes in the cellular landscape of peroxisome-deficient pex3 yeast cells

February 20, 2025

To uncover the consequences of peroxisome deficiency, we compared Saccharomyces cerevisiae wild-type with pex3 cells, which lack peroxisomes, employing quantitative proteomics and transcriptomics technologies.

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