Forty-five-year evolution of probiotic therapy
Authors:Scarlett Puebla-Barragan1,2 and Gregor Reid1,2
doi: 10.15698/mic2019.04.673
Volume 6, pp. 184 to 196, published 01/04/2019.
1 Departments of Microbiology & Immunology, and Surgery, Western University.
2 Lawson Health Research Institute.
Keywords:
probiotics, Lactobacillus, urogenital, cardiovascular, gastrointestinal, therapy.
Corresponding Author(s):
Conflict of interest statement:
SPB has no conflicts of interests. GR is a consultant for Seed, a company producing probiotics.
Please cite this article as:
Scarlett Puebla-Barragan and Gregor Reid (2019). Forty-five-year evolution of probiotic therapy. Microbial Cell 6(4): 184-196. doi: 10.15698/mic2019.04.673
© 2019 Puebla-Barragan and Reid. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.
Abstract:
In the past forty-five years, the field of probiotics has grown from a handful of laboratory studies and clinical ideas into a legitimate research and translational entity conferring multiple benefits to humans around the world. This has been founded upon three principles: (i) the need for alternatives to drugs that either have sub-optimal efficacy or severe adverse effects; (ii) a growing interest in natural products and microbes, in particular catalyzed by studies showing the extent of microbes within humans and on our planet; and (iii) evidence on the genetics and metabolic properties of probiotic strains, and clinical studies showing their effectiveness. While some manufacturers have sadly taken advantage of the market growth to sell supplements and foods they term probiotic, without the necessary human study evidence, there are more and more companies basing their formulations on science. Adherence to the definition of what constitutes a probiotic, conclusions based on tested products not generalizations of the whole field, and applications emanating from microbiome research identifying new strains that provide benefits, will make the next forty-five years significantly changed approaches to health management. Exciting applications will emerge for cardiovascular, urogenital, respiratory, brain, digestive and skin health, detoxification, as well as usage across the world’s ecosystems.