Endomembrane remodeling and dynamics in Salmonella infection
Authors:Ziyan Fang1 and Stéphane Méresse1
doi: 10.15698/mic2022.02.769
Volume 9, pp. 24 to 41, published 27/12/2021.
1 Aix Marseille University, CNRS, INSERM, CIML, Marseille, France.
Keywords:
Salmonella, molecular motors, type 3 secretion system, effectors
Corresponding Author(s):
Conflict of interest statement:
The authors declare no conflict of interest.
Please cite this article as:
Ziyan Fang and Stéphane Méresse (2021). Endomem-brane remodeling and dynamics in Salmonella infection. Microbial Cell 9(2): 24-41. doi: 10.15698/mic2022.02.769
© 2021 Fang and Méresse. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduc-tion in any medium, provided the original author and source are acknowledged.
Abstract:
Salmonellae are bacteria that cause moderate to severe infections in humans, depending on the strain and the immune status of the infected host. These pathogens have the particularity of residing in the cells of the infected host. They are usually found in a vacuolar compartment that the bacteria shape with the help of effector proteins. Following invasion of a eukaryotic cell, the bacterial vacuole undergoes maturation characterized by changes in localization, composition and morphology. In particular, membrane tubules stretching over the microtubule cytoskeleton are formed from the bacterial vacuole. Although these tubules do not occur in all infected cells, they are functionally important and promote intracellular replication. This review focuses on the role and significance of membrane compartment remodeling observed in infected cells and the bacterial and host cell pathways involved.