Using microbial metalo-aminopeptidases as targets in human infectious diseases

Authors:

Jorge González-Bacerio1,2, Maikel Izquierdo1, Mirtha Elisa Aguado1, Ana C. Varela1, Maikel González-Matos1 and Maday Alonso del Rivero1

doi: 10.15698/mic2021.10.761
Volume 8, pp. 239 to 246, published 09/08/2021.

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Affiliations:

1 Center for Protein Studies, Faculty of Biology, University of Havana, calle 25 #455 entre I y J, 10400, Vedado, La Habana, Cuba.

2 Department of Biochemistry, Faculty of Biology, University of Havana, calle 25 #455 entre I y J, 10400, Vedado, La Habana, Cuba.

Keywords: 

microbial metalo-aminopeptidases, molecular targets, human infectious diseases.

Corresponding Author(s):

Jorge González-Bacerio, Center for Protein Studies and Department of Biochemistry, Faculty of Biology, University of Havana, calle 25 #455 entre I y J, 10400, Vedado, La Habana, Cuba; jogoba@fbio.uh.cu

Conflict of interest statement:

The authors declare no conflict of interest.

Please cite this article as:

Jorge González-Bacerio, Maikel Izquierdo, Mirtha Elisa Aguado, Ana C. Varela, Maikel González-Matos and Maday Alonso del Rive-ro (2021). Several microbial metalo-aminopeptidases as targets in human infectious diseases. Microbial Cell 8(10): 239-246. doi: 10.15698/mic2021.10.761

© 2021 González-Bacerio et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and re-production in any medium, provided the original author and source are acknowledged.

Abstract:

Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and pathogenesis. For another group, it is not clear if their enzymatic activity is involved in the critical functions that they mediate. But one aspect has been established: they display relevant roles in bacteria and protozoa that could be targeted for therapeutic purposes. This work aims to describe these biological functions for several microbial metalo-aminopeptidases.