A new role for the nuclear basket network

Authors:

Paola Gallardo1, Silvia Salas-Pino1 and Rafael R. Daga1
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Affiliations:

1 Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas, Junta de Andalucia, Seville, Spain.

Keywords: 

Alm1, TPR nucleoporins, nuclear pore complex, proteasome, kinetochore, fission yeast.

Related Article(s)? 

Salas-Pino S, Gallardo P, Barrales RR, Braun S, Daga RR (2017). The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. J Cell Biol 216(11): 3591-3608. , 10.1083/jcb.201612194

Corresponding Author(s):

Silvia Salas-Pino, CABD/UPO. Carretera de Utrera, Km1. Sevilla, 41013. Spain ssalpin@upo.es Rafael R. Daga, CABD/UPO. Carretera de Utrera, Km1. Sevilla, 41013. Spain rroddag@upo.es

Conflict of interest statement:

The authors declare no competing financial interests.

Please cite this article as:

Paola Gallardo, Silvia Salas-Pino and Rafael R. Daga (2017). A new role for the nuclear basket network. Microbial Cell 4(12): 423-425. doi: 10.15698/mic2017.12.604

© 2017 Gallardo et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

Abstract:

Our view of the nuclear pore complexes (NPCs) as gateways between the nuclear and cytoplasmic compartments has been largely expanded in recent years. NPCs have now demonstrated roles in genome regulation and maintenance from single cells to multicellular organisms. Both NPC proteins as well as components of the NPC basket act as dynamic scaffolds for silencing factors, and chromatin and cell cycle regulators. Components of the NPC basket also couple mRNA production and export, and prevent the exit of unprocessed mRNAs from the nucleus. Our recent work describes a novel function of the fission yeast nuclear basket component – the translocated promoter region (TPR) nucleoporin Alm1 – in proper localization of the proteasome to the nuclear envelope. Here we discuss how regulation of proteasome localization to the nuclear envelope by Alm1 is key to maintain kinetochores homeostasis and proper chromosome segregation.

doi: 10.15698/mic2017.12.604
Volume 4, pp. 423 to 425, published 27/11/2017.